130-10056-200

antibody from RayBiotech, Inc.

Targeting: XIAP API3, BIRC4, hILP, ILP-1

ELISA (Recommended by provider)

Antibody Data

Product number

130-10056-200

Provider

RayBiotech, Inc.

Proper citation

RayBiotech Cat#130-10056-200, RRID:AB_11217410

Product name

Rabbit Anti-Human XIAP

Antibody type

Polyclonal

Antigen

Synthetic peptide derived from human XIAP.

Description

XIAP is an apoptotic suppressor which has E3 ubiquitin-protein ligase activity. XIAP mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1, inhibit caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography.

Reactivity

Human

Host

Rabbit

Antigen sequence

This antibody was produced from a r
abbit immunized with the immunogen.
The IgG fraction was purified from
rabbit serum by ammonium sulphate
precipitation, and followed by Prot
ein A/G affinity chromatography.


Isotype

IgG

Vial size

200 µg

Handling

Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles.