Antibody data

Product number
10-7004 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-DNMT3a Antibody
Antibody type
Monoclonal
Description
Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
Full length recombinant DNMT3a prot
ein was used as the immunogen for t
his antibody
Isotype
IgG
Antibody clone number
ABM1F35
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
DNMT3A protein structure - 10-7004 shown in red.