CABT-B9034

antibody from Creative Diagnostics

Targeting: ERN1 IRE1, IRE1P

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B9034

Provider

Creative Diagnostics

Product name

Anti-IRE1Ï« polyclonal antibody

Antibody type

Polyclonal

Description

The gene ERN1 (endoplasmic reticulum to nucleus signaling 1) encodes an ER transmembrane kinase/endoribonuclease that is also referred to as IRE1ϫ (inositol-requiring transmembrane kinase and endonuclease 1ϫ). The serine-threonine protein kinase encoded by this gene is ubiquitously expressed in cells and tissues. It serves as an ER stress sensor that initiates the splicing of the mRNA encoding X-boxÿbinding protein 1 (XBP-1) upon activation. Spliced XBP-1 mRNA produces homeostatic transcription factor XBP1. Under ER stress, the RNase activity of IRE1ϫ cleaves many ER-localized mRNAs associated with apoptosis. The cytosolic motif of the activated form of IRE1ϫ associates with the adaptor protein TRAF2 (tumor necrosis factor (TNF)ÿassociated factor 2). This complex activates the c-Jun N-terminal kinase (JNK) signaling pathway.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

?20°C