Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [3]
- Immunohistochemistry [2]
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Validation data
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- Product number
- ABIN259945 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Beclin 1, Autophagy Related (BECN1) (AA 150-300), (Internal Region) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Canine, Porcine, Simian
- Host
- Rabbit
- Epitope
- AA 150-300, Internal Region
- Vial size
- 0.05 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy.
Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.
IRE1α promotes viral infection by conferring resistance to apoptosis.
Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice.
Human Rad23A plays a regulatory role in autophagy.
Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells.
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
Hinokitiol induces autophagy in murine breast and colorectal cancer cells.
Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway.
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine.
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Autophagy-related gene expression analysis of wild-type and atg5 gene knockout mouse embryonic fibroblast cells treated with polyethylenimine.
Autophagy enhances the replication of classical swine fever virus in vitro.
HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B.
Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42.
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.
8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers.
PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury.
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Effect of autophagy on multiple myeloma cell viability.
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Consequences of the selective blockage of chaperone-mediated autophagy.
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E, Desplats P
Frontiers in molecular neuroscience 2017;10:329
Frontiers in molecular neuroscience 2017;10:329
Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.
Mortezavi A, Salemi S, Rupp NJ, Rüschoff JH, Hermanns T, Poyet C, Randazzo M, Simon HU, Moch H, Sulser T, Wild P, Eberli D
Oncotarget 2017 May 9;8(19):31765-31774
Oncotarget 2017 May 9;8(19):31765-31774
IRE1α promotes viral infection by conferring resistance to apoptosis.
Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A
Science signaling 2017 Jun 6;10(482)
Science signaling 2017 Jun 6;10(482)
Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice.
Li Y, Wang F, Luo Y
The Journal of surgical research 2017 Jan;207:181-189
The Journal of surgical research 2017 Jan;207:181-189
Human Rad23A plays a regulatory role in autophagy.
Tan X, Wang HC, Liang RY, Chuang SM
Biochemical and biophysical research communications 2016 Sep 30;478(4):1772-9
Biochemical and biophysical research communications 2016 Sep 30;478(4):1772-9
Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells.
Pei J, Deng J, Ye Z, Wang J, Gou H, Liu W, Zhao M, Liao M, Yi L, Chen J
Autophagy 2016 Oct 2;12(10):1738-1758
Autophagy 2016 Oct 2;12(10):1738-1758
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
Choi MS, Kim HJ, Ham M, Choi DH, Lee TR, Shin DW
Scientific reports 2016 Jun 27;6:28476
Scientific reports 2016 Jun 27;6:28476
Hinokitiol induces autophagy in murine breast and colorectal cancer cells.
Wang WK, Lin ST, Chang WW, Liu LW, Li TY, Kuo CY, Hsieh JL, Lee CH
Environmental toxicology 2016 Jan;31(1):77-84
Environmental toxicology 2016 Jan;31(1):77-84
Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z, Li M
Autophagy 2016 Aug 2;12(8):1372-89
Autophagy 2016 Aug 2;12(8):1372-89
Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway.
Yao J, Zheng K, Li C, Liu H, Shan X
Medical oncology (Northwood, London, England) 2015 Jun;32(6):610
Medical oncology (Northwood, London, England) 2015 Jun;32(6):610
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
Lin HH
Chemical research in toxicology 2015 Feb 16;28(2):202-15
Chemical research in toxicology 2015 Feb 16;28(2):202-15
Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine.
Lin CW, Jan MS, Kuo JH
Molecular pharmaceutics 2015 Aug 3;12(8):2858-68
Molecular pharmaceutics 2015 Aug 3;12(8):2858-68
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Lee YH, Chen HY, Su LJ, Chueh PJ
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
Autophagy-related gene expression analysis of wild-type and atg5 gene knockout mouse embryonic fibroblast cells treated with polyethylenimine.
Lin CW, Jan MS, Kuo JH
Molecular pharmaceutics 2014 Sep 2;11(9):3002-8
Molecular pharmaceutics 2014 Sep 2;11(9):3002-8
Autophagy enhances the replication of classical swine fever virus in vitro.
Pei J, Zhao M, Ye Z, Gou H, Wang J, Yi L, Dong X, Liu W, Luo Y, Liao M, Chen J
Autophagy 2014 Jan;10(1):93-110
Autophagy 2014 Jan;10(1):93-110
HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B.
Song JX, Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z, Zhang HQ, Li M
Autophagy 2014 Jan;10(1):144-54
Autophagy 2014 Jan;10(1):144-54
Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
Baldo B, Soylu R, Petersén A
PloS one 2013;8(12):e83050
PloS one 2013;8(12):e83050
BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42.
Nah J, Pyo JO, Jung S, Yoo SM, Kam TI, Chang J, Han J, Soo A An S, Onodera T, Jung YK
Autophagy 2013 Dec;9(12):2009-21
Autophagy 2013 Dec;9(12):2009-21
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.
Zhirnov OP, Klenk HD
Journal of virology 2013 Dec;87(24):13107-14
Journal of virology 2013 Dec;87(24):13107-14
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.
Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Münz C
The Journal of cell biology 2013 Dec 9;203(5):757-66
The Journal of cell biology 2013 Dec 9;203(5):757-66
8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers.
Polotskaia A, Hoffman S, Krett NL, Shanmugam M, Rosen ST, Bargonetti J
Molecular cancer therapeutics 2012 Nov;11(11):2495-504
Molecular cancer therapeutics 2012 Nov;11(11):2495-504
PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ
Autophagy 2011 Oct;7(10):1132-44
Autophagy 2011 Oct;7(10):1132-44
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
Neely KM, Green KN, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 23;31(8):2781-91
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 23;31(8):2781-91
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury.
Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr, Gottlieb RA, Przyklenk K
Circulation 2010 Sep 14;122(11 Suppl):S179-84
Circulation 2010 Sep 14;122(11 Suppl):S179-84
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM
Molecular and cellular biology 2009 May;29(10):2570-81
Molecular and cellular biology 2009 May;29(10):2570-81
Effect of autophagy on multiple myeloma cell viability.
Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A
Molecular cancer therapeutics 2009 Jul;8(7):1974-84
Molecular cancer therapeutics 2009 Jul;8(7):1974-84
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V
The Journal of cell biology 2009 Jul 27;186(2):255-68
The Journal of cell biology 2009 Jul 27;186(2):255-68
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, Codogno P
The Journal of biological chemistry 2009 Jan 30;284(5):2719-28
The Journal of biological chemistry 2009 Jan 30;284(5):2719-28
Consequences of the selective blockage of chaperone-mediated autophagy.
Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM
Proceedings of the National Academy of Sciences of the United States of America 2006 Apr 11;103(15):5805-10
Proceedings of the National Academy of Sciences of the United States of America 2006 Apr 11;103(15):5805-10
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B
Genomics 1999 Jul 1;59(1):59-65
Genomics 1999 Jul 1;59(1):59-65
Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B
Nature 1999 Dec 9;402(6762):672-6
Nature 1999 Dec 9;402(6762):672-6
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, Herman B, Levine B
Journal of virology 1998 Nov;72(11):8586-96
Journal of virology 1998 Nov;72(11):8586-96
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Supportive validation
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