351328

antibody from BioLegend
Targeting: IL7R CD127, IL7RA
Provider product page for 351328

Antibody data

Product number
351328 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#351328, RRID:AB_2562908
Product name
Brilliant Violet 711™ anti-human CD127 (IL-7Ra)
Antibody type
Monoclonal
Antigen
Recombinant human CD127
Description
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
Reactivity
Human
Host
Mouse
Conjugate
Near infrared dye
Antibody clone number
A019D5
Vial size
100 tests
Storage
2°C-8°C
Handling
Ambient RT
IL7R protein structure - 351328 shown in red.