NBP2-48398

antibody from Novus Biologicals
Targeting: GPC3 DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1
Provider product page for NBP2-48398

Antibody data

Product number
NBP2-48398 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal Glypican 3 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
Reactivity
Human, Rat
Host
Mouse
Isotype
IgG
Vial size
7 ml
Storage
Store at 4C.
GPC3 protein structure - NBP2-48398 shown in red.