ABIN955189

antibody from antibodies-online

Targeting: ALYREF ALY, ALY/REF, BEF, REF, THOC4

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN955189

Provider

antibodies-online

Product name

anti-THO Complex 4 (THOC4) (AA 59-89), (Middle Region) antibody

Antibody type

Polyclonal

Description

Protein A column followed by peptide affinity purification

Reactivity

Human

Host

Rabbit

Epitope

AA 59-89, Middle Region

Vial size

0.4 mL

Storage

Store at 2 - 8°C for up to six months or (in aliquots) at -20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA.

Corbin-Lickfett KA, Rojas S, Li L, Cocco MJ, Sandri-Goldin RM
Journal of virology 2010 Mar;84(5):2212-22

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Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.

Souki SK, Sandri-Goldin RM
Journal of virology 2009 Sep;83(17):8970-5

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Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

Katahira J, Inoue H, Hurt E, Yoneda Y
The EMBO journal 2009 Mar 4;28(5):556-67

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Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication.

Colgan KJ, Boyne JR, Whitehouse A
The Journal of general virology 2009 Jun;90(Pt 6):1455-60

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The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.

Johnson LA, Li L, Sandri-Goldin RM
Journal of virology 2009 Jul;83(13):6335-46

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB