ABIN966529

antibody from antibodies-online

Targeting: MAPK7 BMK1, ERK5, PRKM7

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN966529

Provider

antibodies-online

Product name

anti-Mitogen-Activated Protein Kinase 7 (MAPK7) (Isoform 1), (pSer731), (pThr733) antibody

Antibody type

Polyclonal

Antigen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human MAPK7 (mitogen-activated protein kinase 7 isoform 1)

Reactivity

Human, Mouse, Rat

Epitope

Isoform 1,pSer731,pThr733

Vial size

0.1 mg

References

Submitted references

Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target.

Montero JC, Ocaña A, Abad M, Ortiz-Ruiz MJ, Pandiella A, Esparís-Ogando A
PloS one 2009;4(5):e5565

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ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.

Zen K, Yasui K, Nakajima T, Zen Y, Zen K, Gen Y, Mitsuyoshi H, Minami M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T, Yoshikawa T
Genes, chromosomes & cancer 2009 Feb;48(2):109-20

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Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells.

Zhao Z, Geng J, Ge Z, Wang W, Zhang Y, Kang W
Molecular and cellular biochemistry 2009 Feb;322(1-2):171-8

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A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.

Sawhney RS, Liu W, Brattain MG
Journal of cellular physiology 2009 Apr;219(1):152-61

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Erk5 controls Slug expression and keratinocyte activation during wound healing.

Arnoux V, Nassour M, L'Helgoualc'h A, Hipskind RA, Savagner P
Molecular biology of the cell 2008 Nov;19(11):4738-49

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Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.

Esparís-Ogando A, Díaz-Rodríguez E, Montero JC, Yuste L, Crespo P, Pandiella A
Molecular and cellular biology 2002 Jan;22(1):270-85

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Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.

Buschbeck M, Eickhoff J, Sommer MN, Ullrich A
The Journal of biological chemistry 2002 Aug 16;277(33):29503-9

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Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids.

Purandare SM, Lee JD, Patel PI
Cytogenetics and cell genetics 1998;83(3-4):258-9

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.

Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD
Nature 1998 Oct 15;395(6703):713-6

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Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

English JM, Pearson G, Baer R, Cobb MH
The Journal of biological chemistry 1998 Feb 13;273(7):3854-60