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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 362805 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#362805, RRID:AB_2566475
- Product name
- Alexa Fluor® 647 anti-human CD41/CD61
- Antibody type
- Monoclonal
- Antigen
- Human platelets
- Description
- The gpIIb/IIIa complex, also known as integrin αIIbβ3, is expressed by megakaryocytes and platelets. It undergoes conformational changes upon activation by substances, such as ADP, thrombin, and TXA2, which subsequently reveals a ligand binding site that is specific for fibrinogen, von Willebrand factor (vWF), fibronectin, and vitronectin. This conformational change is crucial for platelet-platelet adhesion. Ligand bound gpIIb/IIIa complex promotes platelet aggregation. This complex plays an important role in hemostasis and is a target for developing therapeutic antibodies in immune thrombocytopenia.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antibody clone number
- PAC-1
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- ADP activated enriched human platelets (top) or resting platelets (bottom) were co-stained with CD62P PE and anti-human CD41/CD61 (glycoprotein IIb/IIIa) complex (clone PAC-1) Alexa Fluor® 647.
- Conjugate
- Red dye
