orb76170

antibody from Biorbyt

Targeting: CSTB CST6, EPM1, PME, STFB

Western blot (Recommended by provider)

Antibody Data

Product number

orb76170

Provider

Biorbyt

Product name

Cystatin B antibody

Antibody type

Polyclonal

Description

Rabbit Polyclonal to Cystatin B. Cystatin B(CSTB),also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.

Reactivity

Rat

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 μg

Concentration

0.1-0.5 μg/ml

Storage

Store at -20°C for one year.After reconstitution, at 4°C. for one month. It can also be aliquotted and stored frozen at -20°C. for a longer time.Avoid repeated freezing and thawing.