ABIN1001891

antibody from antibodies-online

Targeting: BACE2 AEPLC, ALP56, CEAP1, DRAP

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN1001891

Provider

antibodies-online

Product name

anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) antibody

Antibody type

Polyclonal

Antigen

Rabbit polyclol BACE2 antibody was raised against a synthetic peptide (APTPGPGTPAERHADG) corresponding to amino acids 44 to 59 of human BACE2 .

Description

Affinity chromatography purified via peptide column.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

N-Term

Isotype

IgG

Vial size

100 μg

Storage

4°C

Handling

Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container?s cap.

References

Submitted references

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M
Science (New York, N.Y.) 1999 Oct 22;286(5440):735-41

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Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G
Molecular and cellular neurosciences 1999 Dec;14(6):419-27

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Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V
Nature 1999 Dec 2;402(6761):537-40

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME
Nature 1999 Dec 2;402(6761):533-7