NBP2-34579PEATT594

antibody from Novus Biologicals

Targeting: CD33 FLJ00391, p67, SIGLEC-3, SIGLEC3

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-34579PEATT594

Provider

Novus Biologicals

Product name

Mouse Monoclonal Siglec-3/CD33 Antibody

Antibody type

Monoclonal

Description

Protein A purified. Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.