346108

antibody from BioLegend
Targeting: CSF3R CD114, GCSFR
Provider product page for 346108

Antibody data

Product number
346108 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#346108, RRID:AB_2083866
Product name
APC anti-human CD114 (G-CSFR)
Antibody type
Monoclonal
Antigen
CHO cells transfected with hG-CSFR
Description
CD114 is the receptor of the colony stimulating factor 3 (CSF3, G-CSF), consist of two 130 kD, type I transmembrane chains that form a homodimer. The extracellular domain consists of an immunoglobulin-like domain, a cytokine receptor homologue domain, and three fibronectin type III repeats. CD114 is expressed in all stages of granulocyte differentiation and in monocytes, platelets, endothelial cells, placenta and trophoblasts. The binding of CSF3, results in the activation of many signaling molecules such as Syk, Lyn, Jak1, Jak2, Tyk2, SOCS3, SOCS1, STAT5, and Shp1, resulting in the expression of different target genes that will increase neutrophil precursor survival, proliferation and maturation. In mature neutrophils, it increases survival, superoxide anion generation, arachidonic acid release, production of myeloperoxidase and leukocyte alkaline phosphatase (LAP).
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Isotype
IgG
Vial size
100 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
CSF3R protein structure - 346108 shown in red.