13-3259-80

antibody from Invitrogen Antibodies
Targeting: CDH2 CD325, CDHN, NCAD
Provider product page for 13-3259-80

Antibody data

Product number
13-3259-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD325 (N-Cadherin) Monoclonal Antibody (8C11), Biotin, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130 kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.
Conjugate
Biotin
Antibody clone number
8C11
Concentration
0.5 mg/mL
CDH2 protein structure - 13-3259-80 shown in red.