320012

antibody from BioLegend
Targeting: FOXP3 AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID
Provider product page for 320012
Flow cytometry

Antibody data

Product number
320012 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#320012, RRID:AB_439748
Product name
Alexa Fluor® 488 anti-mouse/rat/human FOXP3 [150D]
Antibody type
Monoclonal
Antigen
full-length FOXP3 protein
Description
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Reactivity
Human, Mouse, Rat, Simian
Host
Mouse
Conjugate
Green dye
Isotype
IgG
Vial size
100 tests
Storage
The FOXP3 antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
FOXP3 protein structure - 320012 shown in red.