320115

FOXP3 antibody from BioLegend
AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Antibody data

Product number
320115
Provider
BioLegend
Proper citation
BioLegend Cat#320115, RRID:AB_439800
Product name
Pacific Blue™ anti-human FOXP3 [206D]
Provider product page
BioLegend - 320115
Antibody type
Monoclonal
Antigen
full-length FOXP3 protein
Description
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 206D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.
Reactivity
Human, Simian
Host
Mouse
Conjugate
Blue dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Provider Type Product Number
- No reagents -