MB0008

antibody from Bioworld Technology, Inc
Targeting: SMC1A DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb
Provider product page for MB0008

Antibody data

Product number
MB0008 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SMC1A (C terminus) monoclonal antibody
Antibody type
Monoclonal
Antigen
Synthetic peptide, corresponding to the C-terminus of Human SMC1A.
Description
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SMC1A protein structure - MB0008 shown in red.