orb167670

antibody from Biorbyt

Targeting: OCRL Dent-2, OCRL1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

orb167670

Provider

Biorbyt

Product name

INPP5b antibody (Alkaline Phosphatase)

Antibody type

Monoclonal

Description

Mouse monoclonal antibody to INPP5b (Alkaline Phosphatase). Inositol polyphosphate 5-phosphatase OCRL-1 (ORCL) is also called Lowe oculocerebrorenal syndrome protein. ORCL is a phosphotase that converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, as well as inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. ORCL is involved in primary cilia assembly and may also have a role in lysosomal membrane trafficking. ORCL is expressed in brain, skeletal muscle, heart, kidney, lung, placenta, fibroblasts, retina and the retinal pigment epithelium. OCRL defects can cause Lowe oculocerebrorenal syndrome (OCRL) and Dent disease type 2 (DD2).

Reactivity

Human, Rat

Host

Mouse

Conjugate

Alkaline Phosphatase

Isotype

IgG

Antibody clone number

S166A-26

Vial size

100 μg

Concentration

1 mg/ml

Storage

Store at 4°C.