orb149795

ATP7A antibody from Biorbyt
MNK
Western blot
Recommended by provider
Immunoprecipitation
Recommended by provider
Immunohistochemistry
Recommended by provider

Antibody data

Product number
orb149795
Provider
Biorbyt
Product name
Anti-Copper Transporting ATPase 1 antibody (HRP)
Provider product page
Biorbyt - orb149795
Antibody type
Monoclonal
Description
Mouse monoclonal to Copper Transporting ATPase 1 (HRP). The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage..
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Horseradish Peroxidase
Isotype
IgG
Antibody clone number
S60-4
Vial size
100 μg
Concentration
1 mg/ml
Storage
Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Provider Type Product Number
- No reagents -