60088AZ

antibody from STEMCELL Technologies Inc

Targeting: CXCR3 CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

60088AZ

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD183 (CXCR3) Antibody, Clone G025H7, APC

Antibody type

Monoclonal

Description

The G025H7 antibody reacts with an extracellular epitope on human CD183 (CXCR3). CD183 is an ~40 kDa seven-pass G protein-coupled transmembrane chemokine receptor expressed predominantly on the surface of IL2-activated (Th1) T cells, as well as on natural killer (NK) cells, dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. Binding of chemokines to CD183 induces cellular responses involved in leukocyte migration into inflamed tissue, including Ca2+ mobilization, integrin activation, cytoskeletal rearrangements and chemotaxis, and consequently CD183 plays roles in several inflammatory and autoimmune diseases. Three ligands for CD183 have been identified; Mig (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11), with the latter exhibiting the highest affinity for CD183 and the most potent induction of the chemotactic response. These chemokines are secreted by a variety of cells upon stimulation by IFN-gamma.

Reactivity

Human

Isotype

IgG

Vial size

100 Tests

Storage

2 - 8°C