17-2045-42

antibody from Invitrogen Antibodies
Targeting: MSR1 CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII
Provider product page for 17-2045-42

Antibody data

Product number
17-2045-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD204 Monoclonal Antibody (PSL204), APC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
This monoclonal antibody PSL204 reacts with human CD204, also known as Macrophage Scavenger Receptor 1 (MSR1), Scavenger Receptor Type A (SR-A), or SCARA1. It is expressed by multiple populations of macrophages and dendritic cells. CD204 belongs to the class A family of scavenger receptors, a group of five homotrimetric transmembrane proteins that contain a short cytoplasmic tail and extracellular C -terminus. Other members of this family include: MARCO (SCARA2), CSR (SCARA3), SRCL (SCARA4) and SCARA5. CD204 binds and internalizes oxidized low density lipoproteins (LDL), which drives macrophage differentiation into foam cells, secretion of inflammatory cytokines, and development of atherosclerotic lesions. In addition to oxidized LDL, CD204 binds and uptakes a wide variety of macromolecules, including bacterial cell wall components, viral DNA, calciprotein complexes, apoptotic cells, and beta-amyloid fibrils. This broad binding specificity implicates CD204-expressing macrophages in a number of physiological processes and pathologies, such as host defense, inflammation, bone remodeling, atherosclerosis, sepsis, and Alzheimer's disease.
Antibody clone number
PSL204
Concentration
5 µL/Test
MSR1 protein structure - 17-2045-42 shown in red.