12-9744-42
antibody from Invitrogen Antibodies
Targeting: CXCL10
C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 12-9744-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CXCL10 (IP-10) Monoclonal Antibody (4NY8UN), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 4NY8UN monoclonal antibody reacts with human CXCL10. CXCL10, also known as Interferon Inducible Protein-10 (IP-10), is a member of the CXC family of chemokines. It is secreted by monocytes, epithelial cells, and endothelial cells in response to IFN gamma or other pro-inflammatory cytokines and stimuli. CXCL10 signaling is mediated by the G protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. In addition to its chemotactic functions, CXCL10 is a potent inhibitor of angiogenesis and tumor growth and modulates expression of adhesion molecules. Elevated levels of CXCL10 are observed in response to allergic inflammation, various infections, and Alzheimer's disease.
- Conjugate
- Yellow dye
- Antibody clone number
- 4NY8UN
- Concentration
- 5 µL/Test
Submitted references IP-10 induces dissociation of newly formed blood vessels.
Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells.
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Bodnar RJ, Yates CC, Rodgers ME, Du X, Wells A
Journal of cell science 2009 Jun 15;122(Pt 12):2064-77
Journal of cell science 2009 Jun 15;122(Pt 12):2064-77
Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells.
Hung CH, Chu YT, Hua YM, Hsu SH, Lin CS, Chang HC, Lee MS, Jong YJ
The European respiratory journal 2008 Jun;31(6):1313-21
The European respiratory journal 2008 Jun;31(6):1313-21
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B
The Journal of experimental medicine 1996 Sep 1;184(3):963-9
The Journal of experimental medicine 1996 Sep 1;184(3):963-9
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Normal human peripheral blood cells were unstimulated (left) or stimulated for 5 hours with Human IFN gamma Recombinant Protein (Product # 14-8319-80) in the presence of Protein Transport Inhibitor Cocktail (Product # 00-4980-03) (right). Cells were intracellularly stained with Anti-Human CD14 APC (Product # 17-0149-42) and Anti-Human CXCL10 (IP-10) PE using the Intracellular Fixation and Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Cells in the monocyte gate were used for analysis.
- Conjugate
- Yellow dye