NBP2-47684JF646

antibody from Novus Biologicals
Targeting: KRT17 PCHC1
Provider product page for NBP2-47684JF646
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-47684JF646 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal Cytokeratin 17 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Reactivity
Human, Rat, Goat, Porcine, Simian
Host
Mouse
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
KRT17 protein structure - NBP2-47684JF646 shown in red.