BS4028

antibody from Bioworld Technology, Inc
Targeting: BTK AGMX1, ATK, IMD1, PSCTK1, XLA
Provider product page for BS4028

Antibody data

Product number
BS4028 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BTK (phospho Y222) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human BTK around the phosphorylation site of Tyrosine 222.
Description
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BTK protein structure - BS4028 shown in red.