Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- AF2534 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal MMR/CD206/Mannose Receptor Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human MMR/CD206 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse MMR is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms.
Interaction with tumor‑associated macrophages promotes PRL‑3‑induced invasion of colorectal cancer cells via MAPK pathway‑induced EMT and NF‑κB signaling‑induced angiogenesis.
Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese.
Skewed macrophage polarization in aging skeletal muscle.
A glucose-responsive insulin therapy protects animals against hypoglycemia.
Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia.
FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides.
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity.
Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords.
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Nielsen MC, Andersen MN, Rittig N, Rødgaard-Hansen S, Grønbaek H, Moestrup SK, Møller HJ, Etzerodt A
Journal of leukocyte biology 2019 Nov;106(5):1129-1138
Journal of leukocyte biology 2019 Nov;106(5):1129-1138
Interaction with tumor‑associated macrophages promotes PRL‑3‑induced invasion of colorectal cancer cells via MAPK pathway‑induced EMT and NF‑κB signaling‑induced angiogenesis.
Zhang T, Liu L, Lai W, Zeng Y, Xu H, Lan Q, Su P, Chu Z
Oncology reports 2019 May;41(5):2790-2802
Oncology reports 2019 May;41(5):2790-2802
Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese.
Liu B, Hutchison AT, Thompson CH, Lange K, Heilbronn LK
Obesity research & clinical practice 2019 Jul - Aug;13(4):408-415
Obesity research & clinical practice 2019 Jul - Aug;13(4):408-415
Skewed macrophage polarization in aging skeletal muscle.
Cui CY, Driscoll RK, Piao Y, Chia CW, Gorospe M, Ferrucci L
Aging cell 2019 Dec;18(6):e13032
Aging cell 2019 Dec;18(6):e13032
A glucose-responsive insulin therapy protects animals against hypoglycemia.
Yang R, Wu M, Lin S, Nargund RP, Li X, Kelly T, Yan L, Dai G, Qian Y, Dallas-Yang Q, Fischer PA, Cui Y, Shen X, Huo P, Feng DD, Erion MD, Kelley DE, Mu J
JCI insight 2018 Jan 11;3(1)
JCI insight 2018 Jan 11;3(1)
Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia.
Malada-Edelstein YF, Hadad N, Levy R
Journal of neuroinflammation 2017 Feb 10;14(1):33
Journal of neuroinflammation 2017 Feb 10;14(1):33
FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides.
Øie CI, Snapkov I, Elvevold K, Sveinbjørnsson B, Smedsrød B
PloS one 2016;11(8):e0160602
PloS one 2016;11(8):e0160602
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
Millar NL, Gilchrist DS, Akbar M, Reilly JH, Kerr SC, Campbell AL, Murrell GAC, Liew FY, Kurowska-Stolarska M, McInnes IB
Nature communications 2015 Apr 10;6:6774
Nature communications 2015 Apr 10;6:6774
Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity.
Spencer M, Yang L, Adu A, Finlin BS, Zhu B, Shipp LR, Rasouli N, Peterson CA, Kern PA
PloS one 2014;9(7):e102190
PloS one 2014;9(7):e102190
Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords.
Kuo HS, Tsai MJ, Huang MC, Chiu CW, Tsai CY, Lee MJ, Huang WC, Lin YL, Kuo WC, Cheng H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 16;31(11):4137-47
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 16;31(11):4137-47
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, De Palma M
Cancer cell 2011 Apr 12;19(4):512-26
Cancer cell 2011 Apr 12;19(4):512-26
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human MMR/CD206 by Western Blot. Western blot shows lysates of human immature dendritic cells. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2534) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for MMR/CD206 at approximately 185 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.