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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 321123 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#321123, RRID:AB_10900995
- Product name
- PE/Cy7 anti-human CD206 (MMR)
- Antibody type
- Monoclonal
- Antigen
- Purified human mannose receptor
- Description
- Macrophage mannose receptor (MMR) is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor (MR). It is a pattern recognition receptor (PRR) that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Infrared dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with 15-2 PE/Cy7 (filled histogram) or mouse IgG1 κ PE/Cy7 isotype control (open histogram).
- Conjugate
- Near infrared dye
