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- Product number
- ABIN2850435 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sequestosome 1 (SQSTM1) (AA 317-346), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 317-346, C-Term
- Antibody clone number
- RB4614
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis.
Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis.
Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy.
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage.
Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice.
Induction of an incomplete autophagic response by cancer-preventive geranylgeranoic acid (GGA) in a human hepatoma-derived cell line.
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1.
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.
Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis.
Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance.
Helicobacter pylori impairs murine dendritic cell responses to infection.
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.
Roles of SIRT1 in the acute and restorative phases following induction of inflammation.
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.
Familial Paget's disease in The Netherlands: occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations.
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Zhang R, Li Y, Wang Z, Chen L, Dong X, Nie X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Nov;36(11):8585-92
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Nov;36(11):8585-92
Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis.
Sansanwal P, Li L, Sarwal MM
Journal of the American Society of Nephrology : JASN 2015 Mar;26(3):612-25
Journal of the American Society of Nephrology : JASN 2015 Mar;26(3):612-25
Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy.
Tan Q, Joshua AM, Saggar JK, Yu M, Wang M, Kanga N, Zhang JY, Chen X, Wouters BG, Tannock IF
British journal of cancer 2015 Mar 3;112(5):832-40
British journal of cancer 2015 Mar 3;112(5):832-40
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Wu S, Zhang YG, Lu R, Xia Y, Zhou D, Petrof EO, Claud EC, Chen D, Chang EB, Carmeliet G, Sun J
Gut 2015 Jul;64(7):1082-94
Gut 2015 Jul;64(7):1082-94
A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.
Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA
Molecular cancer therapeutics 2013 May;12(5):663-74
Molecular cancer therapeutics 2013 May;12(5):663-74
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu QC, Chen IM, Atlas SR, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA
Blood 2013 Apr 4;121(14):2689-703
Blood 2013 Apr 4;121(14):2689-703
Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage.
Han J, Pan XY, Xu Y, Xiao Y, An Y, Tie L, Pan Y, Li XJ
Autophagy 2012 May 1;8(5):812-25
Autophagy 2012 May 1;8(5):812-25
Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice.
Soontornniyomkij V, Risbrough VB, Young JW, Soontornniyomkij B, Jeste DV, Achim CL
Age (Dordrecht, Netherlands) 2012 Apr;34(2):305-16
Age (Dordrecht, Netherlands) 2012 Apr;34(2):305-16
Induction of an incomplete autophagic response by cancer-preventive geranylgeranoic acid (GGA) in a human hepatoma-derived cell line.
Okamoto K, Sakimoto Y, Imai K, Senoo H, Shidoji Y
The Biochemical journal 2011 Nov 15;440(1):63-71
The Biochemical journal 2011 Nov 15;440(1):63-71
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Déglon N, Pereira de Almeida L
Brain : a journal of neurology 2011 May;134(Pt 5):1400-15
Brain : a journal of neurology 2011 May;134(Pt 5):1400-15
Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1.
Lee HM, Shin DM, Yuk JM, Shi G, Choi DK, Lee SH, Huang SM, Kim JM, Kim CD, Lee JH, Jo EK
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 15;186(2):1248-58
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 15;186(2):1248-58
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.
Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD Jr, Ruan DT
Molecular cancer research : MCR 2010 Sep;8(9):1217-26
Molecular cancer research : MCR 2010 Sep;8(9):1217-26
Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis.
Maynard AA, Dvorak K, Khailova L, Dobrenen H, Arganbright KM, Halpern MD, Kurundkar AR, Maheshwari A, Dvorak B
American journal of physiology. Gastrointestinal and liver physiology 2010 Sep;299(3):G614-22
American journal of physiology. Gastrointestinal and liver physiology 2010 Sep;299(3):G614-22
Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance.
Chu YT, Wang YH, Wu JJ, Lei HY
Infection and immunity 2010 Oct;78(10):4157-65
Infection and immunity 2010 Oct;78(10):4157-65
Helicobacter pylori impairs murine dendritic cell responses to infection.
Wang YH, Gorvel JP, Chu YT, Wu JJ, Lei HY
PloS one 2010 May 27;5(5):e10844
PloS one 2010 May 27;5(5):e10844
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.
Kobayashi S, Volden P, Timm D, Mao K, Xu X, Liang Q
The Journal of biological chemistry 2010 Jan 1;285(1):793-804
The Journal of biological chemistry 2010 Jan 1;285(1):793-804
Roles of SIRT1 in the acute and restorative phases following induction of inflammation.
Zhang Z, Lowry SF, Guarente L, Haimovich B
The Journal of biological chemistry 2010 Dec 31;285(53):41391-401
The Journal of biological chemistry 2010 Dec 31;285(53):41391-401
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.
Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 24;106(8):2770-5
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 24;106(8):2770-5
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.
Ju JS, Miller SE, Hanson PI, Weihl CC
The Journal of biological chemistry 2008 Oct 31;283(44):30289-99
The Journal of biological chemistry 2008 Oct 31;283(44):30289-99
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.
Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW
Molecular and cellular biology 2004 Sep;24(18):8055-68
Molecular and cellular biology 2004 Sep;24(18):8055-68
Familial Paget's disease in The Netherlands: occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations.
Eekhoff EW, Karperien M, Houtsma D, Zwinderman AH, Dragoiescu C, Kneppers AL, Papapoulos SE
Arthritis and rheumatism 2004 May;50(5):1650-4
Arthritis and rheumatism 2004 May;50(5):1650-4
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G
The Journal of biological chemistry 2004 Mar 26;279(13):12804-11
The Journal of biological chemistry 2004 Mar 26;279(13):12804-11
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