orb152266

antibody from Biorbyt

Targeting: SOD1 ALS, ALS1, IPOA

Western blot (Recommended by provider)

Antibody Data

Product number

orb152266

Provider

Biorbyt

Product name

SOD1 antibody (ATTO-633)

Antibody type

Polyclonal

Description

Rabbit polyclonal to SOD1 (ATTO-633). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as SOD1 (EDI), which targets an exposed region of the dimer interface (EDI) of SOD1, are useful for determining the conformation of SOD1 in affected tissues. This antibody can be used in conjunction with SOD1 (U beta B) (SPC-205D) which detects an unfolded beta barrel (U beta B) of SOD1..

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Red dye

Vial size

100 μg

Concentration

1 mg/ml

Storage

Store at 2-8°C and -20°C for one year. (Shipped on ice packs)