Antibody data
- Antibody Data
- Antigen structure
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- Product number
- PABL-718 - Provider product page
- Provider
- Creative Biolabs
- Product name
- Human Anti-TFPI Recombinant Antibody (clone mAb 2021)
- Antibody type
- Monoclonal
- Description
- Recombinant Human Antibody (mAb 2021) is capable of binding to TFPI, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TFPI mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TFPI proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This high-affinity (K(D) = 25pM) mAb against TFPI was investigated. Binding of mAb 2021 to TFPI effectively prevented inhibition of FVIIa/TF/FXa and improved clot formation in hemophilia blood and plasma.
- Reactivity
- Human
- Antibody clone number
- mAb 2021
- Storage
- Centrifuge briefly prior to opening vial. Store at +4¡ãC short term (1-2 weeks). Aliquot and store at -20¡ãC long term. Avoid repeated freeze/thaw cycles.
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