301304

antibody from BioLegend

Targeting: ITGAM CD11B, CR3A, MAC-1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

301304

Provider

BioLegend

Proper citation

BioLegend Cat#301304, RRID:AB_314156

Product name

Biotin anti-human CD11b

Antibody type

Monoclonal

Antigen

CD11b

Description

CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.

Reactivity

Human, Porcine, Simian

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C. Do not freeze.

References

Submitted references

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.

Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE
Infection and immunity 2010 Nov;78(11):4936-43

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Basophils and the T helper 2 environment can promote the development of lupus nephritis.

Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood granulocytes stained with biotinylated ICRF44, followed by SAV-PE

Conjugate

Biotin