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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [1]
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- Product number
- 12-7823-41 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IL-23 p19 Monoclonal Antibody (23dcdp), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rbeta1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORgammat expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells.
- Conjugate
- Yellow dye
- Antibody clone number
- 23dcdp
- Concentration
- 5 µL/Test
Submitted references Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD.
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation.
Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit.
Stensland ZC, Coleman BM, Rihanek M, Baxter RM, Gottlieb PA, Hsieh EWY, Sarapura VD, Simmons KM, Cambier JC, Smith MJ
iScience 2022 Jan 21;25(1):103626
iScience 2022 Jan 21;25(1):103626
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation.
Zhou WJ, Yang HL, Mei J, Chang KK, Lu H, Lai ZZ, Shi JW, Wang XH, Wu K, Zhang T, Wang J, Sun JS, Ye JF, Li DJ, Zhao JY, Jin LP, Li MQ
Science advances 2022 Feb 25;8(8):eabj2488
Science advances 2022 Feb 25;8(8):eabj2488
Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit.
Kalim KW, Groettrup M
Molecular immunology 2013 Mar;53(3):274-82
Molecular immunology 2013 Mar;53(3):274-82
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Intracellular staining of unstimulated (left) or LPS-stimulated in the presence of Protein Transport Inhibitor Cocktail (Product # 00-4980-03) (right) in vitro-cultured human dendritic cells with Anti-Human IL-12/23 p40 eFluor® 660 (Product # 50-7235-42) and Anti-Human IL-23 p19 PE. Total viable cells were used for analysis.
- Conjugate
- Yellow dye
