46-7823-42

antibody from Invitrogen Antibodies
Targeting: IL23A IL-23, IL-23A, IL23P19, P19, SGRF
Provider product page for 46-7823-42

Antibody data

Product number
46-7823-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
IL-23 p19 Monoclonal Antibody (23dcdp), PerCP-eFluor™ 710, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12R\beta1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in ROR\gammat expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as agonists of the \beta-glucan receptor, Dectin-1. Our studies suggest donor, kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
Antibody clone number
23dcdp
Concentration
5 µL/Test
IL23A protein structure - 46-7823-42 shown in red.