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antibody from Invitrogen Antibodies
Targeting: CD44
CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1
Other assayAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Other assay [1]
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- Product number
- BMS118 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD44var (v7-v8) Monoclonal Antibody (VFF-17), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: Specifically recognizes an epitope encoded by exons v7-v8 on the variant portion of human CD44.
- Antibody clone number
- VFF-17
- Concentration
- 1 mg/mL
Submitted references CD44 alternative splicing senses intragenic DNA methylation in tumors via direct and indirect mechanisms.
Hyaluronidase reduces human breast cancer xenografts in SCID mice.
Batsché E, Yi J, Mauger O, Kornobis E, Hopkins B, Hanmer-Lloyd C, Muchardt C
Nucleic acids research 2021 Jun 21;49(11):6213-6237
Nucleic acids research 2021 Jun 21;49(11):6213-6237
Hyaluronidase reduces human breast cancer xenografts in SCID mice.
Shuster S, Frost GI, Csoka AB, Formby B, Stern R
International journal of cancer 2002 Nov 10;102(2):192-7
International journal of cancer 2002 Nov 10;102(2):192-7
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- 3 Staining of xenograft breast tumor sections. Tumors were obtained from SCID mice bearing human tumors derived from the breast carcinoma cell line MDA435. Sections were stained for HA, CD44s and CD44 variant v7-8. Tumors were harvested on Day 12 after the start of hyaluronidase treatment. Treatment consisted of 4 i.v. injections of 75 rTRU of hyaluronidase on Days 0, 2, 4 and 6. Histolocalization of HA using the biotinylated hyaluronan-binding peptide in ( a ) untreated mice with mock inoculation and ( b ) after hyaluronidase treatments. Immunolocalization of CD44s using monoclonal antibodies in ( c ) untreated mice and ( d ) after hyaluronidase treatment. Immunolocalization of CD44 variant v7-8 in ( e ) untreated mice and ( f ) after hyaluronidase treatment. Magnification = x200.
