CABT-B1577

antibody from Creative Diagnostics

Targeting: PON1 ESA, PON

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B1577

Provider

Creative Diagnostics

Product name

Anti-PON1 polyclonal antibody

Antibody type

Polyclonal

Description

Serum paraoxonase/arylesterase 1 (PON 1), also known as Aromatic esterase 1 (A-esterase 1) or K-45 or Serum aryldialkylphosphatase 1, and encoded by the gene name PON1 or PON, is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins that belongs to the paraoxonase family. PON1 hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. This protein has been implicated in protection from atherosclerosis. PON 1 possesses both antioxidant and anti-inflammatory properties. Protecting LDL and HDL from lipid peroxidation, PON 1 degrades specific oxidized cholesteryl esters and oxidized phospholipids contained in lipoproteins. PON1 is expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. Mutations in PON1 have been associated with Microvascular complications of diabetes 5.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.