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- Antigen structure
- References [17]
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- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- ABIN676673 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN676673, RRID:AB_11188020
- Product name
- anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 15-65), (pSer40) antibody
- Antibody type
- Polyclonal
- Description
- Purified by Protein A.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- AA 15-65, pSer40
- Isotype
- IgG
- Vial size
- 100 μL
- Storage
- Store at -20°C
Submitted references EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage.
Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis.
Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.
Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells.
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.
Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells.
Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.
Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation.
Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways.
Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells.
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice.
Monascin and AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation.
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.
Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia.
Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo.
Kim MH, Kim EH, Jung HS, Yang D, Park EY, Jun HS
Toxicology and applied pharmacology 2017 Jan 15;315:60-69
Toxicology and applied pharmacology 2017 Jan 15;315:60-69
Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
Ghosh A, Abdo S, Zhao S, Wu CH, Shi Y, Lo CS, Chenier I, Alquier T, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD
Endocrinology 2017 Apr 1;158(4):903-919
Endocrinology 2017 Apr 1;158(4):903-919
Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis.
Ko SH, Rho da J, Jeon JI, Kim YJ, Woo HA, Lee YK, Kim JM
Infection and immunity 2016 Sep;84(9):2541-54
Infection and immunity 2016 Sep;84(9):2541-54
Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.
Allard JS, Perez EJ, Fukui K, Carpenter P, Ingram DK, de Cabo R
Behavioural brain research 2016 Mar 15;301:1-9
Behavioural brain research 2016 Mar 15;301:1-9
Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells.
Ko SH, Rho DJ, Jeon JI, Kim YJ, Woo HA, Kim N, Kim JM
Infection and immunity 2016 Aug;84(8):2162-2174
Infection and immunity 2016 Aug;84(8):2162-2174
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.
Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR
Translational research : the journal of laboratory and clinical medicine 2016 Apr;170:57-72
Translational research : the journal of laboratory and clinical medicine 2016 Apr;170:57-72
Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells.
Santofimia-Castaño P, Clea Ruy D, Garcia-Sanchez L, Jimenez-Blasco D, Fernandez-Bermejo M, Bolaños JP, Salido GM, Gonzalez A
Free radical biology & medicine 2015 Oct;87:226-36
Free radical biology & medicine 2015 Oct;87:226-36
Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.
Kaneko YS, Takayanagi T, Nagasaki H, Kodani Y, Nakashima A, Mori K, Suzuki A, Itoh M, Kondo K, Nagatsu T, Ota M, Ota A
Journal of neural transmission (Vienna, Austria : 1996) 2015 Jun;122(6):757-72
Journal of neural transmission (Vienna, Austria : 1996) 2015 Jun;122(6):757-72
Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation.
Chang WC, Wu SC, Xu KD, Liao BC, Wu JF, Cheng AS
Molecules (Basel, Switzerland) 2015 Feb 9;20(2):2786-801
Molecules (Basel, Switzerland) 2015 Feb 9;20(2):2786-801
Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, Wanibuchi H
PloS one 2014;9(11):e113610
PloS one 2014;9(11):e113610
Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways.
Li YN, Guo Y, Xi MM, Yang P, Zhou XY, Yin S, Hai CX, Li JG, Qin XJ
Oxidative medicine and cellular longevity 2014;2014:320513
Oxidative medicine and cellular longevity 2014;2014:320513
Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells.
Patwardhan RS, Sharma D, Checker R, Sandur SK
Free radical biology & medicine 2014 Mar;68:52-64
Free radical biology & medicine 2014 Mar;68:52-64
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice.
Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X, Han X, Li J, Yang M, Wang Z, Wei D, Xiao H
Antioxidants & redox signaling 2014 Feb 1;20(4):574-88
Antioxidants & redox signaling 2014 Feb 1;20(4):574-88
Monascin and AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation.
Hsu WH, Lee BH, Li CH, Hsu YW, Pan TM
Journal of agricultural and food chemistry 2013 Jun 26;61(25):5996-6006
Journal of agricultural and food chemistry 2013 Jun 26;61(25):5996-6006
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.
Lee BH, Hsu WH, Hsu YW, Pan TM
Free radical biology & medicine 2013 Jul;60:7-16
Free radical biology & medicine 2013 Jul;60:7-16
Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia.
Lee BH, Lee CC, Cheng YH, Chang WC, Hsu WH, Wu SC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:492-8
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:492-8
Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo.
Lee BH, Hsu WH, Chang YY, Kuo HF, Hsu YW, Pan TM
Free radical biology & medicine 2012 Dec 1;53(11):2008-16
Free radical biology & medicine 2012 Dec 1;53(11):2008-16
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Supportive validation
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- antibodies-online (provider)
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- IHC
- Submitted by
- antibodies-online (provider)
- Main image
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- IHC
- Submitted by
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- Main image
- Experimental details
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