NB100-64359APCCY7

antibody from Novus Biologicals

Targeting: SERPINB9 CAP3, PI9

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NB100-64359APCCY7

Provider

Novus Biologicals

Product name

Mouse Monoclonal SerpinB9 Antibody

Antibody type

Monoclonal

Description

Protein G purified. NB100-64359 is specific for human PI-9 (proteinase inhibitor 9), also known as SerpinB9, a 42kDa intracellular nucleocytoplasmic serpin expressed in cytotoxic lymphocytes (CTLs), natural killer (NK) cells, monocyte-derived dendritic cells (DCs), and to a lesser extent in B cells and myeloid cells. Granzyme B (grB) is a serine protease highly expressed by CTLs and NK cells, which is endocytosed by virus-infected and malignant target cells. The subsequent release of grB from the endocytic vesicles into the cytoplasm of the target cells, triggers grB-mediated apoptosis, through cleavage of various cytoplasmic or nuclear proteins. PI-9, up-regulated in response to grB production and degranulation, has been identified as a potent inhibitor of Granzyme B-mediated apoptosis, providing a vital self-protection mechanism against the premature apoptosis of CTLs and NK cells by grB, which may escape into the cytoplasm of the effector cells themselves. Clone 7D8 detects a band of approximately 42kDa under reducing conditions. Clone 7D8 is suitable for use in indirect Immunofluorescence (2).

Reactivity

Human, Mouse, Porcine

Host

Mouse

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.