Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [3]
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Validation data
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- Product number
- NBP2-48472 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal TOP1MT Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 7 ml
- Storage
- Store at 4C.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TOP1MT Antibody (TOP1MT/488) - IHC-Prediluted [NBP2-48472] - Human Pancreas stained with Topo I, MT Monoclonal Antibody (TOP1MT/488).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TOP1MT Antibody (TOP1MT/488) - IHC-Prediluted [NBP2-48472] - Human Melanoma stained with Topo I, MT Monoclonal Antibody (TOP1MT/488).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TOP1MT Antibody (TOP1MT/488) - IHC-Prediluted [NBP2-48472] - Human Gallbladder stained with Topo I, MT Monoclonal Antibody (TOP1MT/488).