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LearnABIN1169237
antibody from antibodies-online
Targeting: TNFRSF10A
Apo2, CD261, DR4, TRAILR-1, TRAILR1
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations [0]
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- Product number
- ABIN1169237 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) antibody
- Antibody type
- Monoclonal
- Antigen
- Recombinant human TRAIL-R1 (DR4).
- Description
- Purified from concentrated hybridoma tissue culture supernatant.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- HS101
- Vial size
- 100 μg
- Concentration
- 1mg/ml
- Storage
- Stable for at least 1 year after receipt when stored at -20°C.
Submitted references IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells.
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway.
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation.
TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus.
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
Tecchio C, Huber V, Scapini P, Calzetti F, Margotto D, Todeschini G, Pilla L, Martinelli G, Pizzolo G, Rivoltini L, Cassatella MA
Blood 2004 May 15;103(10):3837-44
Blood 2004 May 15;103(10):3837-44
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H
Cell death and differentiation 2004 Jul;11 Suppl 1:S86-96
Cell death and differentiation 2004 Jul;11 Suppl 1:S86-96
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway.
Secchiero P, Melloni E, Heikinheimo M, Mannisto S, Di Pietro R, Iacone A, Zauli G
Blood 2004 Jan 15;103(2):517-22
Blood 2004 Jan 15;103(2):517-22
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation.
Leverkus M, Sprick MR, Wachter T, Mengling T, Baumann B, Serfling E, Bröcker EB, Goebeler M, Neumann M, Walczak H
Molecular and cellular biology 2003 Feb;23(3):777-90
Molecular and cellular biology 2003 Feb;23(3):777-90
TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus.
Washburn B, Weigand MA, Grosse-Wilde A, Janke M, Stahl H, Rieser E, Sprick MR, Schirrmacher V, Walczak H
Journal of immunology (Baltimore, Md. : 1950) 2003 Feb 15;170(4):1814-21
Journal of immunology (Baltimore, Md. : 1950) 2003 Feb 15;170(4):1814-21
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H
The EMBO journal 2002 Sep 2;21(17):4520-30
The EMBO journal 2002 Sep 2;21(17):4520-30
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