DMAB7546

antibody from Creative Diagnostics

Targeting: LAMB2 LAMS, NPHS5

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

DMAB7546

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMAB7546, RRID:AB_2396567

Product name

Anti-Laminin monoclonal antibody, clone IM-5I4

Antibody type

Monoclonal

Description

Laminins are major proteins in the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, adhesion as well as phenotype and survivalLaminins are trimeric proteins that contain an Ï«-chain, a ÉÇ-chain, and a ÎÛ-chain, found in five, four, and three genetic variants, respectively. The laminin molecules are named according to their chain composition. Thus, laminin-511 contains Ï«5, ÉÇ1, and ÎÛ1 chains. Fourteen other chain combinations have been identified in vivo. The trimeric proteins intersect to form a cross-like structure that can bind to other cell membrane and extracellular matrix molecules. The three shorter arms are particularly good at binding to other lamininmolecules, which allows them to form sheets. The long arm is capable of binding to cells, which helps anchor organized tissue cells to the membrane. The laminins are a family of glycoproteins that are an integral part of the structural scaffolding in almost every tissue of an organism. They are secreted and incorporated into cell-associated extracellular matrices. Laminin is vital for the maintenance and survival of tissues. Defective laminins can cause muscles to form improperly, leading to a form of muscular dystrophy, lethal skin blistering disease (junctionalepidermolysisbullosa) and defects of the kidney filter (nephrotic syndrome).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

IM-5I4

Vial size

1 ea

Storage

+2°C to +8°C