AFC-489CL

antibody from Creative Biolabs

Targeting: MADCAM1 MACAM1

No application information provided.

Antibody Data

Product number

AFC-489CL

Provider

Creative Biolabs

Product name

Afuco? Anti-Human MADCAM1 ADCC Recombinant Antibody (PF-00547659), ADCC Enhanced

Antibody type

Monoclonal

Description

Anti-MADCAM1 ADCC Enhanced Antibody (PF-00547659) is an ADCC enhanced antibody produced by our Afuco? platform. PF-00547659 is an anti-human MAdCAM monoclonal antibody which has potential utility in the treatment of inflammatory conditions by blocking tissue homing of activated ¦Á4¦Â7+ leukocytes. The characterization of a rodent cross-reacting antibody as a surrogate for PF-00547659 in the search for potential pharmacological biomarkers and the determination of efficacious doses was effective in addressing the restricted orthologous cross-reactivity of PF-00547659 and the challenges this poses with respect to efficacy and safety testing.

Reactivity

Human

Storage

Store at 4¡ãC short term (1-2 weeks). Aliquot and store at -20¡ãC long term. Avoid repeated freeze/thaw cycles.