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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [9]
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- Product number
- 2341 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#2341, RRID:AB_330023
- Product name
- Phospho-Chk1 (Ser345) Antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Storage
- -20°C
Submitted references Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
A DNA damage checkpoint response in telomere-initiated senescence.
Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function.
The human decatenation checkpoint.
Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M, Navarra S, Lotti F, Biffoni M, Pilozzi E, Duranti E, Martinelli S, Rinaldo C, Zeuner A, Maugeri-Saccà M, Eramo A, De Maria R
Cell death and differentiation 2012 May;19(5):768-78
Cell death and differentiation 2012 May;19(5):768-78
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
Nam EA, Zhao R, Glick GG, Bansbach CE, Friedman DB, Cortez D
The Journal of biological chemistry 2011 Aug 19;286(33):28707-14
The Journal of biological chemistry 2011 Aug 19;286(33):28707-14
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.
Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M
Molecular and cellular biology 2007 Apr;27(7):2572-81
Molecular and cellular biology 2007 Apr;27(7):2572-81
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G
Oncogene 2004 May 27;23(25):4353-61
Oncogene 2004 May 27;23(25):4353-61
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF
The EMBO journal 2004 Aug 4;23(15):3164-74
The EMBO journal 2004 Aug 4;23(15):3164-74
A DNA damage checkpoint response in telomere-initiated senescence.
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP
Nature 2003 Nov 13;426(6963):194-8
Nature 2003 Nov 13;426(6963):194-8
Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.
Shibata Y, Nakamura T
The Journal of biological chemistry 2002 Jan 4;277(1):746-54
The Journal of biological chemistry 2002 Jan 4;277(1):746-54
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function.
Cliby WA, Lewis KA, Lilly KK, Kaufmann SH
The Journal of biological chemistry 2002 Jan 11;277(2):1599-606
The Journal of biological chemistry 2002 Jan 11;277(2):1599-606
The human decatenation checkpoint.
Deming PB, Cistulli CA, Zhao H, Graves PR, Piwnica-Worms H, Paules RS, Downes CS, Kaufmann WK
Proceedings of the National Academy of Sciences of the United States of America 2001 Oct 9;98(21):12044-9
Proceedings of the National Academy of Sciences of the United States of America 2001 Oct 9;98(21):12044-9
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