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- References [25]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10479-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10479-2-AP, RRID:AB_2057171
- Product name
- Annexin A11 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Annexin A11 antibody (Cat. #10479-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Anatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11.
Dendritic location of dystrophic neurites in FTLD-TDP type C with annexinopathy.
Co-aggregation of annexin A11 and TDP-43 in FTLD/MND with primary lateral sclerosis phenotype.
Sorcin couples Annexin A11 recruitment and ESCRT-III assembly during plasma membrane repair.
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer.
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways.
Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment.
Comprehensive Profiling of Annexins in Neuromuscular Disorders Reveals a Unique Signature in Dysferlinopathy.
Motor involvement in frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa type C.
Non-canonical RNA-binding protein ANXA11 regulates microRNA resorting into small extracellular vesicles to mediate cisplatin resistance.
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C.
Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Adult-onset dominant muscular dystrophy in Greek families caused by Annexin A11.
Urinary extracellular vesicles signature for diagnosis of kidney disease.
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
A Novel Multisystem Proteinopathy Caused by a Missense ANXA11 Variant.
Theme 2 Genetics and genomics.
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.
ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun.
Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression.
Kawles A, Nelson C, Ayala I, Barbieri E, Castellani R, Geula C, Gefen T, Mesulam MM
Annals of neurology 2026 Mar;99(3):639-655
Annals of neurology 2026 Mar;99(3):639-655
Dendritic location of dystrophic neurites in FTLD-TDP type C with annexinopathy.
Kawles A, Zouridakis A, Nelson C, Keszycki R, Minogue G, Macomber A, Jamshidi P, Castellani RJ, Geula C, Gefen T, Mesulam MM
Brain pathology (Zurich, Switzerland) 2026 Jan;36(1):e70032
Brain pathology (Zurich, Switzerland) 2026 Jan;36(1):e70032
Co-aggregation of annexin A11 and TDP-43 in FTLD/MND with primary lateral sclerosis phenotype.
Tarutani A, Nonaka T, Ohtani R, Imai K, Ito Y, Tsuji H, Mochizuki A, Tamaoka A, Arai T, Robinson AC, Mann DMA, Kosaka T, Takahashi H, Kakita A, Yoshida M, Hasegawa M
Acta neuropathologica communications 2026 Jan 4;14(1):34
Acta neuropathologica communications 2026 Jan 4;14(1):34
Sorcin couples Annexin A11 recruitment and ESCRT-III assembly during plasma membrane repair.
Ngo JM, Williams JK, Murugupandiyan A, Schekman R
bioRxiv : the preprint server for biology 2026 Apr 13;
bioRxiv : the preprint server for biology 2026 Apr 13;
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
Ghayal NB, Crook RJ, Jain A, Sachdeva G, Jiang P, Roemer SF, Sekiya H, DeTure MA, Baker MC, De Coster W, Oskarsson B, Josephs KA, Rademakers R, van Blitterswijk MM, Dickson DW
Acta neuropathologica 2025 Nov 12;150(1):52
Acta neuropathologica 2025 Nov 12;150(1):52
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Šneiderienė G, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P
Nature communications 2025 Mar 21;16(1):2814
Nature communications 2025 Mar 21;16(1):2814
Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer.
Liu K, Zhu C, Liang Y, Min D, Jin Z, Sun X
Journal of medicinal chemistry 2025 Mar 13;68(5):5358-5381
Journal of medicinal chemistry 2025 Mar 13;68(5):5358-5381
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease.
Ghayal NB, Crook RJ, Jain A, Sachdeva G, Roemer SF, Sekiya H, DeTure MA, Baker M, Coster W, Oskarsson BE, Josephs KA, Rademakers R, van Blitterswijk M, Dickson DW
bioRxiv : the preprint server for biology 2025 Jun 28;
bioRxiv : the preprint server for biology 2025 Jun 28;
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways.
Zhou L, Yang T, Zhang S, Liu D, Feng C, Ni J, Shi Q, Liu Y, Meng Y, Zhu Y, Tang H, Wang J, Ma A
Journal of molecular medicine (Berlin, Germany) 2025 Jul;103(7):821-836
Journal of molecular medicine (Berlin, Germany) 2025 Jul;103(7):821-836
Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment.
Liu Q, Sun Y, He B, Chen H, Wang L, Wang G, Zhang K, Zhao X, Zhang X, Shen D, Zhang X, Cui L
Acta neuropathologica communications 2025 Jan 4;13(1):2
Acta neuropathologica communications 2025 Jan 4;13(1):2
Comprehensive Profiling of Annexins in Neuromuscular Disorders Reveals a Unique Signature in Dysferlinopathy.
He QF, Lin YH, Zheng ZL, Zeng MH, Lin X, Liu XY, Kang-Yang, Zhang QI, Lin MT, Wang N, Wang ZQ, Lin F
European journal of neurology 2025 Dec;32(12):e70442
European journal of neurology 2025 Dec;32(12):e70442
Motor involvement in frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa type C.
Yamashita R, Beck G, Shigenobu K, Tarutani A, Yonenobu Y, Kawai M, Mori K, Tahara S, Satake Y, Saito Y, Morii E, Hasegawa M, Ikeda M, Mochizuki H, Murayama S
Neuropathology : official journal of the Japanese Society of Neuropathology 2025 Aug;45(4):e13026
Neuropathology : official journal of the Japanese Society of Neuropathology 2025 Aug;45(4):e13026
Non-canonical RNA-binding protein ANXA11 regulates microRNA resorting into small extracellular vesicles to mediate cisplatin resistance.
Zhang Y, Huang Q, Shen Y, Ren H, Wu C, Zhou L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep;38(17):e70048
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep;38(17):e70048
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.
Arseni D, Nonaka T, Jacobsen MH, Murzin AG, Cracco L, Peak-Chew SY, Garringer HJ, Kawakami I, Suzuki H, Onaya M, Saito Y, Murayama S, Geula C, Vidal R, Newell KL, Mesulam M, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature 2024 Oct;634(8034):662-668
Nature 2024 Oct;634(8034):662-668
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C.
Arseni D, Nonaka T, Jacobsen MH, Murzin AG, Cracco L, Peak-Chew SY, Garringer HJ, Kawakami I, Suzuki H, Onaya M, Saito Y, Murayama S, Geula C, Vidal R, Newell KL, Mesulam M, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
bioRxiv : the preprint server for biology 2024 Jun 26;
bioRxiv : the preprint server for biology 2024 Jun 26;
Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
Robinson JL, Suh E, Xu Y, Hurtig HI, Elman L, McMillan CT, Irwin DJ, Porta S, Van Deerlin VM, Lee EB
Acta neuropathologica 2024 Jun 19;147(1):104
Acta neuropathologica 2024 Jun 19;147(1):104
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P
bioRxiv : the preprint server for biology 2023 Mar 24;
bioRxiv : the preprint server for biology 2023 Mar 24;
Adult-onset dominant muscular dystrophy in Greek families caused by Annexin A11.
Johari M, Papadimas G, Papadopoulos C, Xirou S, Kanavaki A, Chrysanthou-Piterou M, Rusanen S, Savarese M, Hackman P, Udd B
Annals of clinical and translational neurology 2022 Oct;9(10):1660-1667
Annals of clinical and translational neurology 2022 Oct;9(10):1660-1667
Urinary extracellular vesicles signature for diagnosis of kidney disease.
Takizawa K, Ueda K, Sekiguchi M, Nakano E, Nishimura T, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J, Hamasaki Y, Hisano M, Omori T, Okamoto T, Kitayama H, Fujita N, Kuramochi H, Ichiki T, Oka A, Harita Y
iScience 2022 Nov 18;25(11):105416
iScience 2022 Nov 18;25(11):105416
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
Teyssou E, Muratet F, Amador MD, Ferrien M, Lautrette G, Machat S, Boillée S, Larmonier T, Saker S, Leguern E, Cazeneuve C, Marie Y, Guegan J, Gyorgy B, Cintas P, Meininger V, Le Forestier N, Salachas F, Couratier P, Camu W, Seilhean D, Millecamps S
Neurobiology of aging 2021 Mar;99:102.e11-102.e20
Neurobiology of aging 2021 Mar;99:102.e11-102.e20
A Novel Multisystem Proteinopathy Caused by a Missense ANXA11 Variant.
Leoni TB, González-Salazar C, Rezende TJR, Hernández ALC, Mattos AHB, Coimbra Neto AR, da Graça FF, Gonçalves JPN, Martinez ARM, Taniguti L, Kitajima JP, Kok F, Rogério F, da Silva AMS, de Oliveira ALR, Zanoteli E, Nucci A, França MC Jr
Annals of neurology 2021 Aug;90(2):239-252
Annals of neurology 2021 Aug;90(2):239-252
Theme 2 Genetics and genomics.
Roggenbuck J, Doyle C, Lincoln T, Glass J
Amyotrophic lateral sclerosis & frontotemporal degeneration 2019 Nov;20(sup1):114-134
Amyotrophic lateral sclerosis & frontotemporal degeneration 2019 Nov;20(sup1):114-134
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.
Smith BN, Topp SD, Fallini C, Shibata H, Chen HJ, Troakes C, King A, Ticozzi N, Kenna KP, Soragia-Gkazi A, Miller JW, Sato A, Dias DM, Jeon M, Vance C, Wong CH, de Majo M, Kattuah W, Mitchell JC, Scotter EL, Parkin NW, Sapp PC, Nolan M, Nestor PJ, Simpson M, Weale M, Lek M, Baas F, Vianney de Jong JM, Ten Asbroek ALMA, Redondo AG, Esteban-Pérez J, Tiloca C, Verde F, Duga S, Leigh N, Pall H, Morrison KE, Al-Chalabi A, Shaw PJ, Kirby J, Turner MR, Talbot K, Hardiman O, Glass JD, De Belleroche J, Maki M, Moss SE, Miller C, Gellera C, Ratti A, Al-Sarraj S, Brown RH Jr, Silani V, Landers JE, Shaw CE
Science translational medicine 2017 May 3;9(388)
Science translational medicine 2017 May 3;9(388)
ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun.
Liu S, Guo C, Wang J, Wang B, Qi H, Sun MZ
Oncotarget 2016 Mar 29;7(13):16297-310
Oncotarget 2016 Mar 29;7(13):16297-310
Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression.
Liu S, Wang J, Guo C, Qi H, Sun MZ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:58-63
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:58-63
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10479-2-AP(ANXA11 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10479-2-AP(ANXA11 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Annexin A11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Annexin A11. This antibody recognizes human,mouse,rat antigen. The Annexin A11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
