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- References [105]
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- Product number
- 10842-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10842-1-AP, RRID:AB_2192672
- Product name
- Alpha Synuclein antibody
- Antibody type
- Polyclonal
- Description
- Alpha Synuclein antibody (Cat. #10842-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TLR4/NF-κB signaling-mediated neuroinflammation is associated with gut microbiota dysbiosis in a mouse model of Parkinson's disease.
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration.
PARK19 truncation mutant Dnajc6 causes lysosomal deficiency-induced upregulation of pathologic α-synuclein and neurodegeneration of substantia nigra dopaminergic cells in PARK19 knockin mice.
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Identification of KHS-101 as a Transcription Factor EB Activator to Promote α-Synuclein Degradation.
Butyrate-Modified Hyaluronic Acid Ameliorates MPTP-Induced Parkinson's Disease via Modulating PINK1/Parkin-Involved Mitophagy and Intestinal Flora.
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4.
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies.
circFKBP8(5S,6)-encoded protein modulates α-synuclein expression in SH-SY5Y cells.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation.
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson's Disease Model: Transcriptomic Evidence.
Absence of Rab39b-induced macroautophagy impairment increases neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in mouse model of X-linked Parkinson's disease.
Evaluating alpha-synuclein proteinopathy and consequences for birdsong in zebra finch basal ganglia area X.
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Exogenous α-Synuclein Induces Oxidative Damage to Dopaminergic Neurons Through p-NMDAR2B/Nur77.
PD-like pathogenesis induced by intestinal exposure to microplastics: An in vivo study of animal models to a public health survey.
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
β-synuclein blocks α-synuclein condensate fusion to disrupt the maturation of phase separation.
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.
A novel mouse model of chronic neuronopathic Gaucher disease exhibits Parkinson's disease-like phenotypes.
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model.
Correction: Akintade, D.D.; Chaudhuri, B. Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria. Cells 2020, 9, 2203.
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice.
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP(+)/MPTP-Induced Parkinson's Disease Model.
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy.
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
[Tianma Gouteng Granule improves motor deficits in mouse models of Parkinson's disease by regulating the necroptosis pathway].
USP18 is a key regulator of immune function in mouse midbrain microglia.
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease.
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
RVG29 Peptide-Modified Exosomes Loaded with Mir-133b Mediate the RhoA-ROCK Pathway to Improve Motor and Neurological Symptoms in Parkinson's Disease.
Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression.
Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson's disease in the Chinese population.
The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics.
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinson's Disease Model Mice.
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein.
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.
Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.
TRPV4-mediated Ca(2+) deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons.
Cdk5 phosphorylation-dependent C9orf72 degradation promotes neuronal death in Parkinson's disease models.
Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.
Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.
The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease.
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.
Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury.
In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Myocardial cathepsin D is downregulated in sudden cardiac death.
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.
Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation.
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease.
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells.
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.
α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis.
Zhang R, Tian M, Wu Y, Yang C, Shi X, Wang S
Frontiers in immunology 2026;17:1672241
Frontiers in immunology 2026;17:1672241
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
Zhai MR, Pan J, Wu ZH, He YY, Zhang KR, Ren L, Wang YR, Li YB, Gao J, Xiao L, Liu YH
Theranostics 2026;16(5):2466-2487
Theranostics 2026;16(5):2466-2487
GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration.
Wen S, Xiang W, Shen F, Jiang N, Ma D, Zhang J
Cell death and differentiation 2026 Mar 31;
Cell death and differentiation 2026 Mar 31;
PARK19 truncation mutant Dnajc6 causes lysosomal deficiency-induced upregulation of pathologic α-synuclein and neurodegeneration of substantia nigra dopaminergic cells in PARK19 knockin mice.
Wang HL, Chen YL, Chiu TJ, Chiu CC, Weng YH, Liu SY, Li AH, Yeh TH
NPJ Parkinson's disease 2026 Mar 12;12(1)
NPJ Parkinson's disease 2026 Mar 12;12(1)
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Yue M, Chen T, Chen W, Wei J, Liao B, Zhang J, Li F, Hong D, Fang X
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Identification of KHS-101 as a Transcription Factor EB Activator to Promote α-Synuclein Degradation.
Zhu H, Ren A, Li T, Zhou T, Li A, Pan X, Chen L, Chen J
International journal of molecular sciences 2026 Jan 16;27(2)
International journal of molecular sciences 2026 Jan 16;27(2)
Butyrate-Modified Hyaluronic Acid Ameliorates MPTP-Induced Parkinson's Disease via Modulating PINK1/Parkin-Involved Mitophagy and Intestinal Flora.
Sun Y, Cui L, Peng W, Chen R, Guan X, Liu J
Biomacromolecules 2026 Jan 12;27(1):134-149
Biomacromolecules 2026 Jan 12;27(1):134-149
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4.
Wright S, Dang VC, Hussain S, Kandel P, Brendza RP, Mazhar S, Whitmore M, Boudoukha S, Kaur Banwait J, Van Der Linden R, Vertudes E, Markham K, Trzeciak M, Pohan G, Jennings A, Shahidi-Latham S, Kayser F, Beckstead M, Lucius AL, Kashyap A, Ischiropoulos H, Griswold-Prenner I
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 10;123(6):e2515002123
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 10;123(6):e2515002123
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies.
Liu H, Chen Y, Li C, Zhang Q, Lin X, Lin Y, Xu Q
Experimental gerontology 2026 Apr;216:113071
Experimental gerontology 2026 Apr;216:113071
circFKBP8(5S,6)-encoded protein modulates α-synuclein expression in SH-SY5Y cells.
Uzoechina J, Zhang Z
Molecular biology reports 2026 Apr 2;53(1)
Molecular biology reports 2026 Apr 2;53(1)
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Huang L, Li Q, Wu J, He Y, Huang J, Xie S, Yang C, Ruan Q, Zhou Z, Deng M
Frontiers in aging neuroscience 2025;17:1568002
Frontiers in aging neuroscience 2025;17:1568002
R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation.
Zhong C, Gao X, Chen Q, Guan B, Wu W, Ma Z, Tao M, Liu X, Ding Y, Fei Y, Liu Y, Lu B, Li Z
Autophagy 2025 Sep;21(9):1945-1961
Autophagy 2025 Sep;21(9):1945-1961
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
Zhou S, Liu Y, Liu Y, Duan Z, Zhu C, Wang P, Fu R
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson's Disease Model: Transcriptomic Evidence.
Lyu P, Wen F, Fu Z, Li J, Li Q, Cai X, Huang S, Qiu X, Zhang Z, Huang Y, Zhang J
Journal of integrative neuroscience 2025 Sep 18;24(9):40105
Journal of integrative neuroscience 2025 Sep 18;24(9):40105
Absence of Rab39b-induced macroautophagy impairment increases neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in mouse model of X-linked Parkinson's disease.
Chiu CC, Weng YH, Yeh TH, Chen WS, Liu SY, Chiu TJ, Li AH, Wang HL
Life sciences 2025 Sep 15;377:123789
Life sciences 2025 Sep 15;377:123789
Evaluating alpha-synuclein proteinopathy and consequences for birdsong in zebra finch basal ganglia area X.
Bjork RT, Patel FZ, Daly MS, Miller JE
Behavioural brain research 2025 Sep 13;493:115698
Behavioural brain research 2025 Sep 13;493:115698
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
Si Y, Yan S, Li X, Ding W, Zhang X, Jia K, Yao L, Yang F, Shi W
Brain research 2025 Oct 15;1865:149824
Brain research 2025 Oct 15;1865:149824
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Zhang Y, Tian S, Niu M, Yang H, Liu L, Kang Y, Yin Y
Neuroscience 2025 Nov 10;587:108-122
Neuroscience 2025 Nov 10;587:108-122
Exogenous α-Synuclein Induces Oxidative Damage to Dopaminergic Neurons Through p-NMDAR2B/Nur77.
Lai X, Wu J, Kou X, Zhang Y, Shen M, Yu M, Zhai Y, Yan J
Molecular neurobiology 2025 May;62(5):5664-5678
Molecular neurobiology 2025 May;62(5):5664-5678
PD-like pathogenesis induced by intestinal exposure to microplastics: An in vivo study of animal models to a public health survey.
Bai H, Gu H, Zhou W, Shi G, Yan J, Su Y, Li W, Li Y, Zhong C, Zhao N, Huang X
Journal of hazardous materials 2025 Mar 15;486:136974
Journal of hazardous materials 2025 Mar 15;486:136974
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
Feng S, Gui J, Qin B, Ye J, Zhao Q, Guo A, Sang M, Sun X
Molecular neurobiology 2025 Jun;62(6):6636-6654
Molecular neurobiology 2025 Jun;62(6):6636-6654
β-synuclein blocks α-synuclein condensate fusion to disrupt the maturation of phase separation.
Xu B, He W, Fan F, Chen S, Zhu M, Hou Y, Zheng L, Yu H, Liu Y
Cell reports 2025 Jun 24;44(6):115761
Cell reports 2025 Jun 24;44(6):115761
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Fu G, Li T, Zhao Y, Zhang S, Xue X, Yang Y, Li T, Luo S, Yue G, Lei T
Chinese medicine 2025 Jun 16;20(1):87
Chinese medicine 2025 Jun 16;20(1):87
Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.
Zhang H, Fan C, Li L, Liu F, Li S, Ma L, Yang Y, Cooper DN, Yang Y, Hu R, Zhao H
NPJ Parkinson's disease 2025 Jun 13;11(1):167
NPJ Parkinson's disease 2025 Jun 13;11(1):167
A novel mouse model of chronic neuronopathic Gaucher disease exhibits Parkinson's disease-like phenotypes.
Wen S, Li Y, Xiang W, Shen F, Jiang N, Ma D, Zhang J
Neurobiology of disease 2025 Jun 1;209:106899
Neurobiology of disease 2025 Jun 1;209:106899
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model.
Kong WX, Zhang ZL, Li J, Zhu S, Li C, Dong XL, Gan TT, Hu D, Liang FC, Xu PY, Guo WY
Journal of neuroinflammation 2025 Jul 5;22(1):174
Journal of neuroinflammation 2025 Jul 5;22(1):174
Correction: Akintade, D.D.; Chaudhuri, B. Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria. Cells 2020, 9, 2203.
Akintade DD, Chaudhuri B
Cells 2025 Jul 22;14(15)
Cells 2025 Jul 22;14(15)
Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1.
Liu L, Liu X, Zhang R, Sun X, Zhang K, Zheng B, Yang R, Yang K, Song G, Zhang Z
Journal of translational medicine 2025 Jul 11;23(1):781
Journal of translational medicine 2025 Jul 11;23(1):781
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice.
Yang X, Zheng R, Zhang H, Ou Z, Wan S, Lin D, Yan J, Jin M, Tan J
Experimental neurology 2025 Jan;383:115007
Experimental neurology 2025 Jan;383:115007
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Cai Z, Liang C, Huang K, Luo J, Lu R, Lai Y, Zheng D, Lin Z, Zhong J, Dai J, Huang J, Zhang H, Chen J
International immunopharmacology 2025 Jan 27;146:113928
International immunopharmacology 2025 Jan 27;146:113928
m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP(+)/MPTP-Induced Parkinson's Disease Model.
Li Z, Chen X, Xiang W, Tang T, Gan L
ACS chemical neuroscience 2025 Feb 5;16(3):405-416
ACS chemical neuroscience 2025 Feb 5;16(3):405-416
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Zhang J, Fu Z, Wen F, Lyu P, Huang S, Cai X, Zhang Z, Zhang Y, Fan C, Man W, Sun X, Huang Y
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy.
Senapati S, Sciortino A, Samples M, Shchankin N, Zhao Y, Montalbano M, Kayed R
Research square 2025 Dec 3;
Research square 2025 Dec 3;
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
Balta D, Varghese A, Prieto Huarcaya S, Di Spiezio A, Marques ARA, Akdaş EY, Tabakacilar D, Drobny A, Werner C, Xiang W, Mächtel R, Dobert JP, Fejtova A, Richter F, Küspert M, Arnold P, Saftig P, Zunke F
Molecular neurodegeneration 2025 Aug 29;20(1):95
Molecular neurodegeneration 2025 Aug 29;20(1):95
[Tianma Gouteng Granule improves motor deficits in mouse models of Parkinson's disease by regulating the necroptosis pathway].
Chen D, Ren Q, Lü M, Zhang B, Liu X, Zhang M, Wang Y, Kou X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1571-1580
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1571-1580
USP18 is a key regulator of immune function in mouse midbrain microglia.
Lu L, Jifu C, Pei B, Gao X, Xu Z, Yin X, Xia J, Wang J
Life sciences 2025 Aug 1;374:123692
Life sciences 2025 Aug 1;374:123692
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Qin X, Wang S, Huang J, Hu B, Yang X, Liang L, Zhou R, Huang W
Frontiers in neuroscience 2024;18:1396345
Frontiers in neuroscience 2024;18:1396345
Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease.
Izquierdo-Altarejos P, Arenas YM, Martínez-García M, Vázquez L, Mincheva G, Doverskog M, Blackburn TP, Bohnen NI, Llansola M, Felipo V
Frontiers in aging neuroscience 2024;16:1417938
Frontiers in aging neuroscience 2024;16:1417938
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Ye J, Sun X, Jiang Q, Gui J, Feng S, Qin B, Xie L, Guo A, Dong J, Sang M
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
Burgueño-García I, López-Martínez MJ, Uceda-Heras A, García-Carracedo L, Zea-Sevilla MA, Rodrigo-Lara H, Rego-García I, Saiz-Aúz L, Ruiz-Valderrey P, López-González FJ, Guerra-Martín V, Rábano A
Journal of clinical medicine 2024 Nov 10;13(22)
Journal of clinical medicine 2024 Nov 10;13(22)
RVG29 Peptide-Modified Exosomes Loaded with Mir-133b Mediate the RhoA-ROCK Pathway to Improve Motor and Neurological Symptoms in Parkinson's Disease.
Jiang P, Xiao Y, Hu X, Wang C, Gao H, Huang H, Lv J, Qi Z, Wang Z
ACS biomaterials science & engineering 2024 May 13;10(5):3069-3085
ACS biomaterials science & engineering 2024 May 13;10(5):3069-3085
Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression.
Fang YY, Teng MJ, Peng JC, Zheng XW, Mo YQ, Ho TT, Lin JJ, Luo JJ, Aschner M, Jiang YM
Ecotoxicology and environmental safety 2024 Jan 15;270:115853
Ecotoxicology and environmental safety 2024 Jan 15;270:115853
Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson's disease in the Chinese population.
Li J, Duan S, Yang J, Zheng H, Yuan Y, Tang M, Wang Y, Liu Y, Xia Z, Luo H, Xu Y
European journal of medical research 2024 Feb 9;29(1):114
European journal of medical research 2024 Feb 9;29(1):114
The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics.
Li K, Ling H, Wang X, Xie Q, Gu C, Luo W, Qiu P
Progress in neuro-psychopharmacology & biological psychiatry 2024 Feb 8;129:110909
Progress in neuro-psychopharmacology & biological psychiatry 2024 Feb 8;129:110909
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Zheng D, Lai Y, Huang K, Guan D, Xie Z, Fu C, Liu L, Huang J, Gong L, Li J, Zhang H, Chen J
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
Frontiers in neurology 2023;14:1255097
Frontiers in neurology 2023;14:1255097
The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinson's Disease Model Mice.
Han J, Liu M, Ling Y, Ren Y, Qiu Y, Liu Y, Yin Y
Journal of Parkinson's disease 2023;13(5):743-756
Journal of Parkinson's disease 2023;13(5):743-756
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652
Journal of translational medicine 2023 Sep 22;21(1):652
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Tong Y, Zhu W, Chen J, Zhang W, Xu F, Pang J
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein.
Chiu CC, Weng YH, Yeh TH, Lu JC, Chen WS, Li AH, Chen YL, Wei KC, Wang HL
Molecular neurobiology 2023 May;60(5):2706-2728
Molecular neurobiology 2023 May;60(5):2706-2728
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.
Drobny A, Boros FA, Balta D, Prieto Huarcaya S, Caylioglu D, Qazi N, Vandrey J, Schneider Y, Dobert JP, Pitcairn C, Mazzulli JR, Zunke F
Translational neurodegeneration 2023 Jun 13;12(1):31
Translational neurodegeneration 2023 Jun 13;12(1):31
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.
Ohgita T, Kono H, Morita I, Oyama H, Shimanouchi T, Kobayashi N, Saito H
Scientific reports 2023 Jul 5;13(1):10885
Scientific reports 2023 Jul 5;13(1):10885
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.
Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R
eLife 2023 Jan 10;12
eLife 2023 Jan 10;12
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.
Brendza R, Gao X, Stark KL, Lin H, Lee SH, Hu C, Cai H, DiCara D, Hsiao YC, Ngu H, Foreman O, Baca M, Dohse M, Fortin JP, Corpuz R, Seshasayee D, Easton A, Ayalon G, Hötzel I, Chih B
Neurobiology of disease 2023 Feb;177:105969
Neurobiology of disease 2023 Feb;177:105969
Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.
Zou W, Zhang K, Qiu Z, Xin R, Wang G, Zhang J, Li J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113584
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113584
TRPV4-mediated Ca(2+) deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons.
Sun X, Kong J, Dong S, Kato H, Sato H, Hirofuji Y, Ito Y, Wang L, Kato TA, Torio M, Sakai Y, Ohga S, Fukumoto S, Masuda K
FASEB bioAdvances 2023 Dec;5(12):507-520
FASEB bioAdvances 2023 Dec;5(12):507-520
Cdk5 phosphorylation-dependent C9orf72 degradation promotes neuronal death in Parkinson's disease models.
Xu X, Li M, Su Y, Wang Q, Qin P, Huang H, Zhang Y, Zhou Y, Yan J
CNS neuroscience & therapeutics 2023 Dec;29(12):3952-3966
CNS neuroscience & therapeutics 2023 Dec;29(12):3952-3966
Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.
Medina CA, Vargas E, Munger SJ, Miller JE
PloS one 2022;17(5):e0265604
PloS one 2022;17(5):e0265604
Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.
Liang F, Chen CY, Li YP, Ke YC, Ho EP, Jeng CF, Lin CH, Chen SK
Journal of Parkinson's disease 2022;12(8):2423-2440
Journal of Parkinson's disease 2022;12(8):2423-2440
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.
Huang J, Ding J, Wang X, Gu C, He Y, Li Y, Fan H, Xie Q, Qi X, Wang Z, Qiu P
Brain, behavior, and immunity 2022 Nov;106:247-261
Brain, behavior, and immunity 2022 Nov;106:247-261
The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice.
Zhao M, Deng L, Lu X, Fan L, Zhu Y, Zhao L
Environmental science and pollution research international 2022 Jun;29(27):41151-41167
Environmental science and pollution research international 2022 Jun;29(27):41151-41167
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease.
Wen J, Zhang YQ, Liu DQ, Yao XT, Jiang H, Zhang YB
Chinese journal of natural medicines 2022 Feb;20(2):111-119
Chinese journal of natural medicines 2022 Feb;20(2):111-119
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.
Zhong J, Li M, Xu J, Dong W, Qin Y, Qiu S, Li X, Wang H
Toxicology and applied pharmacology 2022 Feb 1;436:115859
Toxicology and applied pharmacology 2022 Feb 1;436:115859
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.
Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, Wakabayashi K, Yamada M, Kakita A, Shibata N
Neuropathology : official journal of the Japanese Society of Neuropathology 2022 Dec;42(6):488-504
Neuropathology : official journal of the Japanese Society of Neuropathology 2022 Dec;42(6):488-504
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Wang K, Zhang B, Zhang B, Wu K, Tian T, Yan W, Huang M
Neurotoxicity research 2022 Apr;40(2):520-529
Neurotoxicity research 2022 Apr;40(2):520-529
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.
Ohgita T, Namba N, Kono H, Shimanouchi T, Saito H
Scientific reports 2022 Apr 26;12(1):6770
Scientific reports 2022 Apr 26;12(1):6770
Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury.
Luo W, Yang Z, Zhang W, Zhou D, Guo X, Wang S, He F, Wang Y
Frontiers in molecular neuroscience 2021;14:785938
Frontiers in molecular neuroscience 2021;14:785938
In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.
Chang KH, Huang CY, Ou-Yang CH, Ho CH, Lin HY, Hsu CL, Chen YT, Chou YC, Chen YJ, Chen Y, Lin JL, Wang JK, Lin PW, Lin YR, Lin MH, Tseng CK, Lin CH
Stem cell research & therapy 2021 Sep 22;12(1):508
Stem cell research & therapy 2021 Sep 22;12(1):508
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Gao H, Wang D, Jiang S, Mao J, Yang X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
Dong WL, Zhong JH, Chen YQ, Xie JF, Qin YY, Xu JP, Cai NB, Li MF, Liu L, Wang HT
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295
Journal of neuroinflammation 2021 Dec 20;18(1):295
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
Liu B, Li H, Liu X, Li F, Chen W, Kuang Y, Zhao X, Li L, Yu B, Jin X, Li Q
Cellular signalling 2021 Aug;84:110012
Cellular signalling 2021 Aug;84:110012
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, Sun Z, Han Q, Zhao RC
Aging and disease 2021 Aug;12(5):1211-1222
Aging and disease 2021 Aug;12(5):1211-1222
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Gao H, Wang D, Wang YL, Mao JP, Jiang S, Yang XL
Molecular biology reports 2021 Apr;48(4):3079-3087
Molecular biology reports 2021 Apr;48(4):3079-3087
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64
Acta neuropathologica communications 2021 Apr 8;9(1):64
Myocardial cathepsin D is downregulated in sudden cardiac death.
Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M
PloS one 2020;15(3):e0230375
PloS one 2020;15(3):e0230375
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Akintade DD, Chaudhuri B
Bioscience reports 2020 Sep 30;40(9)
Bioscience reports 2020 Sep 30;40(9)
Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.
Akintade DD, Chaudhuri B
Cells 2020 Sep 29;9(10)
Cells 2020 Sep 29;9(10)
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Chiu CC, Weng YH, Huang YZ, Chen RS, Liu YC, Yeh TH, Lu CS, Lin YW, Chen YJ, Hsu CC, Chiu CH, Wang YT, Chen WS, Liu SY, Wang HL
Cell death & disease 2020 Nov 30;11(11):1018
Cell death & disease 2020 Nov 30;11(11):1018
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Akintade DD, Chaudhuri B
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q
PloS one 2019;14(11):e0225145
PloS one 2019;14(11):e0225145
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL
Frontiers in cellular neuroscience 2019;13:399
Frontiers in cellular neuroscience 2019;13:399
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.
Lin CJ, Lin CY, Lin YT, Huang CY, Wei KC, Chen JC, Lee-Chen GJ, Liu HL
Biochemical and biophysical research communications 2019 Sep 10;517(1):77-83
Biochemical and biophysical research communications 2019 Sep 10;517(1):77-83
Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation.
Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A
Molecular neurobiology 2019 Mar;56(3):1539-1557
Molecular neurobiology 2019 Mar;56(3):1539-1557
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112
Behavioural brain research 2019 Mar 15;360:103-112
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL
Molecular neurobiology 2019 Jun;56(6):3835-3853
Molecular neurobiology 2019 Jun;56(6):3835-3853
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Zhou P, Homberg JR, Fang Q, Wang J, Li W, Meng X, Shen J, Luan Y, Liao P, Swaab DF, Shan L, Liu C
Brain, behavior, and immunity 2019 Feb;76:61-73
Brain, behavior, and immunity 2019 Feb;76:61-73
RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease.
Su J, Wang H, Yang Y, Wang J, Li H, Huang D, Huang L, Bai X, Yu M, Fei J, Huang F
Neurochemistry international 2018 Sep;118:195-204
Neurochemistry international 2018 Sep;118:195-204
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F
Cell death & disease 2018 Jun 13;9(6):700
Cell death & disease 2018 Jun 13;9(6):700
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118
Neural regeneration research 2018 Jan;13(1):112-118
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Koga S, Lin WL, Walton RL, Ross OA, Dickson DW
Neuropathology and applied neurobiology 2018 Dec;44(7):707-721
Neuropathology and applied neurobiology 2018 Dec;44(7):707-721
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
Huang C, Zhu L, Li H, Shi FG, Wang GQ, Wei YZ, Liu J, Zhang F
Frontiers in molecular neuroscience 2017;10:131
Frontiers in molecular neuroscience 2017;10:131
α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells.
Duan J, Ying Z, Su Y, Lin F, Deng Y
Neuroscience letters 2017 Mar 6;642:148-152
Neuroscience letters 2017 Mar 6;642:148-152
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
Tayebi N, Parisiadou L, Berhe B, Gonzalez AN, Serra-Vinardell J, Tamargo RJ, Maniwang E, Sorrentino Z, Fujiwara H, Grey RJ, Hassan S, Blech-Hermoni YN, Chen C, McGlinchey R, Makariou-Pikis C, Brooks M, Ginns EI, Ory DS, Giasson BI, Sidransky E
Molecular genetics and metabolism 2017 Dec;122(4):198-208
Molecular genetics and metabolism 2017 Dec;122(4):198-208
Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.
Marques F, Tenney J, Duran I, Martin J, Nevarez L, Pogue R, Krakow D, Cohn DH, Li B
PLoS genetics 2016 Sep;12(9):e1006307
PLoS genetics 2016 Sep;12(9):e1006307
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.
Rodríguez-Nogales C, Garbayo E, Martínez-Valbuena I, Sebastián V, Luquin MR, Blanco-Prieto MJ
International journal of pharmaceutics 2016 Nov 30;514(1):142-149
International journal of pharmaceutics 2016 Nov 30;514(1):142-149
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, Zhang G, Yang J, Zhang Z, Zhang Z, Lin Z, Xiong N, Wang T
Molecular neurobiology 2016 Mar;53(2):995-1008
Molecular neurobiology 2016 Mar;53(2):995-1008
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 27;35(21):8345-58
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 27;35(21):8345-58
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J
Molecular neurodegeneration 2015 Mar 11;10:8
Molecular neurodegeneration 2015 Mar 11;10:8
Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.
Zhang Y, Ma H, Xie B, Han C, Wang C, Qing H, Deng Y
Neuroscience letters 2013 Jun 28;547:65-9
Neuroscience letters 2013 Jun 28;547:65-9
α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis.
Ying Z, Lin F, Gu W, Su Y, Arshad A, Qing H, Deng Y
Journal of neural transmission (Vienna, Austria : 1996) 2011 Aug;118(8):1165-72
Journal of neural transmission (Vienna, Austria : 1996) 2011 Aug;118(8):1165-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10842-1-AP(SNCA antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10842-1-AP(SNCA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The alpha-synuclein antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human alpha-synuclein. This antibody recognizes human,mouse,rat antigen. The alpha-synuclein antibody has been validated for the following applications: ELISA, WB, IHC analysis.
