11262-2-AP

antibody from Proteintech Group

Targeting: ATG3 APG3L, DKFZp564M1178, FLJ22125, MGC15201, PC3-96

Provider product page for 11262-2-AP

Western blot

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11262-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11262-2-AP, RRID:AB_2059234
Product name: ATG3 antibody
Antibody type: Polyclonal
Description: ATG3 antibody (Cat. #11262-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ATG3 protein structure - 11262-2-AP shown in red.

Submitted references vtRNA1-1/p62 regulates macrophages autophagy in ankylosing spondylitis.

Jiang M, Ni J, Yu X, Zhao H, Lu X, Cheng L, Li Z, Wu H, Pan Z, Qu L, Gao M, Cai G, Wang M, Pan F
Molecular immunology 2026 May;193:1-9

Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy.

Yao J, Zhao Z, Chen Y, Xu X, Yang Y, Yue W, Shi X
Cell death and differentiation 2026 Jan;33(1):188-199

Allergen-induced dendritic cell autophagy drives immune imbalance in asthma.

Li Y, Zhou M, Ren Y, Li Y, Xiang J, Deng F, Yu J, Luo Z, Liu E, Fu Z, Liu B, Ding F
International immunopharmacology 2026 Jan 1;168(Pt 2):115897

Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy.

Suklabaidya S, Mohanty S, Reider IE, White J, Colter D, McCormick SM, Shembade N, Choi YB, Norbury CC, Harhaj EW
Nature communications 2026 Feb 11;17(1)

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.

Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J
Autophagy 2025 Oct;21(10):2148-2167

Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.

Chen W, Liu S, Zhou Y, Liu B, Wang W, Chen C, Lou Z, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657

Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation.

Xu S, Liu P, Jia J, Sun M, Ma F, Mao R, Li H, Ji S, Bao X, Xia S, Xu Y, Cao X
Journal of neuroinflammation 2025 Oct 31;22(1):253

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death.

Yang H, Jiang B, Li W, Du G, Xu F, Zhang Y, Yang Y, Zhang S, Cao W, Li X, Zhang X, Ji T, Wang J
British journal of pharmacology 2025 May;182(10):2310-2331

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer.

Cheng L, Guo M, Farooqi AA, Wang L, Zhang Y, Ye H, Qiao G, Lin X
Discover oncology 2025 Jun 12;16(1):1069

Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates.

White J, Choi YB, Zhang J, Vo MT, He C, Shaikh K, Harhaj EW
Autophagy 2025 Jan;21(1):160-177

Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process.

Hu Z, Li Y, Yao N, Gan H, Zeng Q, Huang X, Huang D, Cai D, Chen Y
Pharmaceutical biology 2025 Dec;63(1):387-401

Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2-mediated autophagy.

Xia Y, Wang D, Zhao H, Meng T, Jiang Q, Pan Z, Wang G, An T, Li B, Bi S, Wang H, Lu J, Liu H, Lin H, Lin C, Zheng Q, Li D
Pharmacological research 2024 Sep;207:107327

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.

Torres P, Rico-Rios S, Ceron-Codorniu M, Santacreu-Vilaseca M, Seoane-Miraz D, Jad Y, Ayala V, Mariño G, Beltran M, Miralles MP, Andrés-Benito P, Fernandez-Irigoyen J, Santamaria E, López-Otín C, Soler RM, Povedano M, Ferrer I, Pamplona R, Wood MJA, Varela MA, Portero-Otin M
Acta neuropathologica 2024 Sep 21;148(1):45

Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.

Lu L, Chen J, Jiang H, Li N, Li X, Liu Y, Zong C
Journal of cellular and molecular medicine 2024 Nov;28(22):e70246

Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis.

Hou LS, Zhai XP, Zhang YW, Xing JH, Li C, Zhou SY, Zhu XH, Zhang BL
Liver international : official journal of the International Association for the Study of the Liver 2024 Aug;44(8):1937-1951

LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4(+) T lymphocytes.

Pradel B, Cantaloube G, Villares M, Deffieu MS, Robert-Hebmann V, Lucansky V, Faure M, Chazal N, Gaudin R, Espert L
Autophagy 2024 Aug;20(8):1825-1836

Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.

Wu Q, Yu S, Zang S, Peng K, Wang Z
Heliyon 2024 Aug 30;10(16):e36131

Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.

Li J, Qin X, Xu W, Zhang H, Huang S, Yang Y, Qin M, Mi Z, Zhong X
The international journal of biochemistry & cell biology 2024 Apr;169:106549

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation.

Zhang J, Jiang N, Du C, Guo H, Meng R, Hou X, Liu M, Hu Y, Cui X
Investigative ophthalmology & visual science 2023 Jun 1;64(7):5

Recombinant humanized collagen type III with high antitumor activity inhibits breast cancer cells autophagy, proliferation, and migration through DDR1.

Liu X, Li H, Wang T, Yang T, Yang X, Guo K, Hu L, Ming J
International journal of biological macromolecules 2023 Jul 15;243:125130

Purvalanol A induces apoptosis and reverses cisplatin resistance in ovarian cancer.

Zhang X, Hong S, Yang J, Liu J, Wang Y, Peng J, Wang H, Hong L
Anti-cancer drugs 2023 Jan 1;34(1):29-43

Toxoplasma gondii CDPK3 Controls the Intracellular Proliferation of Parasites in Macrophages.

Wu M, An R, Zhou N, Chen Y, Cai H, Yan Q, Wang R, Luo Q, Yu L, Chen L, Du J
Frontiers in immunology 2022;13:905142

Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy.

Huang B, Jin L, Zhang L, Cui X, Zhang Z, Lu Y, Yu L, Ma T, Zhang H
Frontiers in cell and developmental biology 2022;10:897666

Analysis of the roles of the Notch1 signalling pathway in modulating deoxynivalenol cytotoxicity.

Xiao Y, Wang J, Wang J, Wang H, Wu S, Bao W
Ecotoxicology and environmental safety 2022 Nov;246:114183

Genome-wide transcriptional profiling and functional analysis reveal miR-330-MAPK15 axis involving in cellular responses to deoxynivalenol exposure.

Wang H, Zhou Y, Xu C, Cao Y, Xiao Y, Cai D, Uemoto Y, Wu S, Bao W
Chemosphere 2022 Jul;298:134199

Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice.

Yang N, Liu X, Niu X, Wang X, Jiang R, Yuan N, Wang J, Zhang C, Lim KL, Lu L
Stem cell reviews and reports 2022 Feb;18(2):626-641

RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.

Chaoqun H, Rong Y, Yunpeng P, Xiaole Z, Wanli G, Chenyuan S, Dongya H, Yi M, Qiang L
Tissue & cell 2022 Dec;79:101940

Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.

Xu G, Chen H, Wu S, Chen J, Zhang S, Shao G, Sun L, Mu Y, Liu K, Pan Q, Li N, An X, Lin S, Chen W
Cell death & disease 2022 Aug 5;13(8):683

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420

Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.

Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889

Resveratrol promotes osteoblastic differentiation in a rat model of postmenopausal osteoporosis by regulating autophagy.

Wang W, Zhang LM, Guo C, Han JF
Nutrition & metabolism 2020;17:29

Autophagy activation and the mechanism of retinal microvascular endothelial cells in hypoxia.

Li R, Wang LZ, Du JH, Zhao L, Yao Y
International journal of ophthalmology 2018;11(4):567-574

7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.

Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)

Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3.

Xiu YL, Sun KX, Chen X, Chen S, Zhao Y, Guo QG, Zong ZH
Oncotarget 2017 May 9;8(19):31714-31725

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.

Wu B, Cui J, Yang XM, Liu ZY, Song F, Li L, Jiang JL, Chen ZN
Cell death & disease 2017 Jul 13;8(7):e2925

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 11262-2-AP(ATG3 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ATG3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ATG3. This antibody recognizes human,mouse,rat antigen. The ATG3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11262-2-AP.pdf

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