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- References [21]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 12316-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12316-1-AP, RRID:AB_2226307
- Product name
- ANGPTL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ANGPTL2 antibody (Cat. #12316-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Increased Production of Angiopoietin-like Protein 2 in a Ligature- and LPS-Induced Periodontitis Mouse Model May Promote Colorectal Tumor Progression.
ANGPTL2 inhibits macrophage pyroptosis and alleviates rheumatoid arthritis progression by regulating mitophagy via IGFBP5.
Roles of Msx2 in exogen control: modulating the stem cell niche during the transition from hair shedding to regeneration.
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer.
Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma.
Periodontitis promotes hepatocellular carcinoma in Stelic Animal model (STAM) mice.
ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer.
Leukocyte immunoglobulin-like receptor B2 overexpression as a promising therapeutic target and noninvasive screening biomarker for colorectal cancer.
Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.
Identification of a Fibroblast-Related Prognostic Model in Glioma Based on Bioinformatics Methods.
Pyrvinium pamoate can overcome artemisinin's resistance in anaplastic thyroid cancer.
PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.
Fucoxanthin Exerts Anti-Tumor Activity on Canine Mammary Tumor Cells via Tumor Cell Apoptosis Induction and Angiogenesis Inhibition.
Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.
Downregulation of angiopoietin-like protein 2 inhibits cementoblast differentiation partially by activating the ERK1/2 signaling pathway.
Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion.
Overexpression of ANGPTL2 and LILRB2 as predictive and therapeutic biomarkers for metastasis and prognosis in colorectal cancer.
Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells.
Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells.
Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer.
Yamashita M, Yamamoto G, Katsumata K, Takeuchi D, Tachikawa N, Ono K, Ohno T, Nishida E, Fujita T, Hayashi JI, Kikuchi T, Sugita Y, Mitani A
Journal of clinical medicine 2026 Mar 19;15(6)
Journal of clinical medicine 2026 Mar 19;15(6)
ANGPTL2 inhibits macrophage pyroptosis and alleviates rheumatoid arthritis progression by regulating mitophagy via IGFBP5.
Liu Y, Yang Q, Huang Z, Sun J, Xiao J, Yang Z, Huang X, Ma L, Wang X, Wang C, Cao Z
Cell death & disease 2026 Mar 12;17(1)
Cell death & disease 2026 Mar 12;17(1)
Roles of Msx2 in exogen control: modulating the stem cell niche during the transition from hair shedding to regeneration.
Chen Q, Jea WC, Jiang TX, Wu P, Zhang C, Li J, Lei M, Chuong CM, Liang YC
Journal of advanced research 2025 Sep 23;
Journal of advanced research 2025 Sep 23;
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
Huang Z, Fang J, Lin L, Cai N, Chen S, He G, Cao Y, Wu G, Wang Y, Li W, Huang Z, Saw PE
Journal of nanobiotechnology 2025 Jul 18;23(1):524
Journal of nanobiotechnology 2025 Jul 18;23(1):524
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer.
Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS
World journal of gastrointestinal oncology 2025 Feb 15;17(2):97858
World journal of gastrointestinal oncology 2025 Feb 15;17(2):97858
Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma.
Hüser L, Chhabra Y, Gololobova O, Wang V, Liu G, Dixit A, Rocha MR, Harper EI, Fane ME, Marino-Bravante GE, Zabransky DJ, Cai KQ, Utikal J, Slusher BS, Walston J, Lipson EJ, Witwer KW, Weeraratna AT
Cell reports 2024 Sep 24;43(9):114721
Cell reports 2024 Sep 24;43(9):114721
Periodontitis promotes hepatocellular carcinoma in Stelic Animal model (STAM) mice.
Ohno T, Kikuchi T, Suzuki Y, Goto R, Takeuchi D, Hayashi JI, Nishida E, Yamamoto G, Kondo S, Ono K, Nomoto S, Mitani A
Scientific reports 2024 Jul 30;14(1):17560
Scientific reports 2024 Jul 30;14(1):17560
ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer.
Liu X, Qin J, Nie J, Gao R, Hu S, Sun H, Wang S, Pan Y
Frontiers in immunology 2023;14:1185208
Frontiers in immunology 2023;14:1185208
Leukocyte immunoglobulin-like receptor B2 overexpression as a promising therapeutic target and noninvasive screening biomarker for colorectal cancer.
Wang QQ, Zhou L, Qin G, Tan C, Zhou YC, Yao SK
World journal of gastroenterology 2023 Oct 7;29(37):5313-5326
World journal of gastroenterology 2023 Oct 7;29(37):5313-5326
Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.
Jiang C, Yao S, Guo Y, Ma L, Wang X, Chen Y, Zhang H, Cao Z
Journal of periodontology 2022 Oct;93(10):1525-1539
Journal of periodontology 2022 Oct;93(10):1525-1539
Identification of a Fibroblast-Related Prognostic Model in Glioma Based on Bioinformatics Methods.
Zhang H, Huang Y, Yang E, Gao X, Zou P, Sun J, Tian Z, Bao M, Liao D, Ge J, Yang Q, Li X, Zhang Z, Luo P, Jiang X
Biomolecules 2022 Oct 30;12(11)
Biomolecules 2022 Oct 30;12(11)
Pyrvinium pamoate can overcome artemisinin's resistance in anaplastic thyroid cancer.
Li Y
BMC complementary medicine and therapies 2021 May 28;21(1):156
BMC complementary medicine and therapies 2021 May 28;21(1):156
PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.
Li J, Peng C, Lai D, Fang Y, Luo D, Zhou Z, Li C, Lai X
Scientific reports 2021 May 26;11(1):10973
Scientific reports 2021 May 26;11(1):10973
Fucoxanthin Exerts Anti-Tumor Activity on Canine Mammary Tumor Cells via Tumor Cell Apoptosis Induction and Angiogenesis Inhibition.
Jang H, Choi J, Park JK, Won G, Seol JW
Animals : an open access journal from MDPI 2021 May 23;11(6)
Animals : an open access journal from MDPI 2021 May 23;11(6)
Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.
Kang Y, Liu J, Yin S, Jiang Y, Feng X, Wu J, Zhang Y, Chen A, Zhang Y, Shao L
ACS nano 2020 Mar 24;14(3):3059-3074
ACS nano 2020 Mar 24;14(3):3059-3074
Downregulation of angiopoietin-like protein 2 inhibits cementoblast differentiation partially by activating the ERK1/2 signaling pathway.
Jiang C, Liu H, Sun H, Wang X, Liao H, Ma L, Cao Z
American journal of translational research 2019;11(1):314-326
American journal of translational research 2019;11(1):314-326
Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion.
Sugimoto K, Nakamura T, Tokunaga T, Uehara Y, Okada T, Taniwaki T, Fujimoto T, Oike Y, Nakamura E
Asian spine journal 2019 Jun;13(3):368-376
Asian spine journal 2019 Jun;13(3):368-376
Overexpression of ANGPTL2 and LILRB2 as predictive and therapeutic biomarkers for metastasis and prognosis in colorectal cancer.
He J, Xu J, Yu X, Zhu H, Zeng Y, Fan D, Yi X
International journal of clinical and experimental pathology 2018;11(5):2281-2294
International journal of clinical and experimental pathology 2018;11(5):2281-2294
Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells.
Ohno T, Yamamoto G, Hayashi JI, Nishida E, Goto H, Sasaki Y, Kikuchi T, Fukuda M, Hasegawa Y, Mogi M, Mitani A
PloS one 2017;12(9):e0184825
PloS one 2017;12(9):e0184825
Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells.
Sato R, Yamasaki M, Hirai K, Matsubara T, Nomura T, Sato F, Mimata H
Oncology reports 2015 Jan;33(1):58-66
Oncology reports 2015 Jan;33(1):58-66
Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer.
Wang L, Geng T, Guo X, Liu J, Zhang P, Yang D, Li J, Yu S, Sun Y
Molecular medicine reports 2015 Apr;11(4):2789-96
Molecular medicine reports 2015 Apr;11(4):2789-96
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 12316-1-AP(ANGPTL2 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 12316-1-AP(ANGPTL2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ANGPTL2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ANGPTL2. This antibody recognizes human,mouse,rat antigen. The ANGPTL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
