Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [104]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12949-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12949-1-AP, RRID:AB_2161499
- Product name
- PDK4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDK4 antibody (Cat. #12949-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Combined high-fat, high-sucrose diet and streptozotocin treatment induces cardiometabolic heart failure with preserved ejection fraction in mice.
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury.
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state.
PDK4 acts via hippo signaling to inhibit ferroptosis and reduce gemcitabine sensitivity in pancreatic cancer.
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ.
Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.
Identification and Experimental Verification of PDK4 as a Potential Biomarker for Diagnosis and Treatment in Rheumatoid Arthritis.
S100A9 inhibition ameliorates HFpEF by modulating mitochondrial fission and oxidative stress.
Kang Shuai Lao Pian exerts anti-aging effects by enhancing mitochondrial oxidative metabolism.
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3.
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.
Regulation of lactate accumulation in bovine mammary epithelial cells by LPS-induced HIF-1α/MCT1 pathway.
FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice.
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation.
Substrate stiffness-dependent metabolic reprogramming of iPSC-derived cardiomyocytes on physiological PDMS polymers.
PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages.
Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis.
Cross-Organ Proteome Analysis Reveals Changes in Protein Expression Related With Glucose and Amino Acid Metabolism in Muscles and Hearts of Torpid Mice.
EGR2 promotes liver cancer metastasis by enhancing IL-8 expression through transcription regulation of PDK4 in M2 macrophages.
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states.
Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein.
Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes.
A novel genetic model provides a unique perspective on the relationship between postexercise glycogen concentration and increases in the abundance of key metabolic proteins after acute exercise.
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4.
G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.
PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury.
Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock.
NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Stevioside Ameliorates Palmitic Acid-Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes.
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Inhibition of glycolysis enhances the efficacy of immunotherapy via PDK-mediated upregulation of PD-L1.
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Eicosapentaenoic acid increases proportion of type 1 muscle fibers through PPARδ and AMPK pathways in rats.
Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.
Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation.
Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation.
Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice.
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy.
A tryptophan-derived uremic metabolite/Ahr/Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease.
Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy.
Identification of PDK4 as Hub Gene for Diabetic Nephropathy Using Co-Expression Network Analysis.
Prognostic value of autophagy-related genes based on single-cell RNA-sequencing in colorectal cancer.
PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer.
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Low-Carbohydrate Diet Modulates Glucose-Lipid Utilization in Skeletal Muscle of Diabetic Mice.
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Acetate controls endothelial-to-mesenchymal transition.
1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation.
Astrocytic FoxO1 in the hypothalamus regulates metabolic homeostasis by coordinating neuropeptide Y neuron activity.
Distinct Transcriptional Responses of Skeletal Muscle to Short-Term Cold Exposure in Tibetan Pigs and Bama Pigs.
Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1α promotes Osteosarcoma Progression and Glycolysis Metabolism.
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice.
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.
Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1α axis and insulin sensitivity.
Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study of Mitochondrial Proteome.
Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells.
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Effects of Dietary Fat Restriction on Endurance Training-induced Metabolic Adaptations in Rat Skeletal Muscle.
Dietary Olive Oil Intake Improves Running Endurance with Intramuscular Triacylglycerol Accumulation in Mice.
Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia.
Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells.
Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.
Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.
Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells.
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia.
MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats.
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.
Heinen A, Spychala A, Ballmann L, Gödecke S, Faradj Z, Bresch F, Krüger M, Bottermann K, Zabri H, Fischer J, Petzsch P, Gödecke A
American journal of physiology. Heart and circulatory physiology 2026 May 1;330(5):H1375-H1390
American journal of physiology. Heart and circulatory physiology 2026 May 1;330(5):H1375-H1390
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury.
Deng Y, Qiu Y, Li X, Gong T, Guo J, Liang H, Yuan Z, Hei Z, Zhang X, Liu Y
Cell death and differentiation 2026 Mar;33(3):557-573
Cell death and differentiation 2026 Mar;33(3):557-573
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
Xin J, Liu R, Deng M, Song Y, Cui Y, Gao J, Zhang B, Feng L, Mu X, Cui J, Li H, Zhu L, Sun Y, Yi W
Journal of translational medicine 2026 Jan 7;24(1):228
Journal of translational medicine 2026 Jan 7;24(1):228
KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state.
Zhang L, Hou N, Wang X, Quan L, Yu Z, Du X, Wu S
Cellular signalling 2026 Feb;138:112214
Cellular signalling 2026 Feb;138:112214
PDK4 acts via hippo signaling to inhibit ferroptosis and reduce gemcitabine sensitivity in pancreatic cancer.
Jin L, Pan M, Yuan X, Zhu X, Gao T, Chen C
Journal of molecular histology 2026 Apr 22;57(3)
Journal of molecular histology 2026 Apr 22;57(3)
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
Gong W, Yang X, Fan N, Wang H, Fu S, Tian Y, Li L
Scientific reports 2026 Apr 18;
Scientific reports 2026 Apr 18;
Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ.
Tanaka S, Hirota A, Okada Y, Obana M, Fujio Y
PloS one 2025;20(5):e0318178
PloS one 2025;20(5):e0318178
Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.
Dong Y, Fu Q, Zhang Y, Weng W, Han P, Cai Y, Sun H
American journal of translational research 2025;17(8):5871-5884
American journal of translational research 2025;17(8):5871-5884
Identification and Experimental Verification of PDK4 as a Potential Biomarker for Diagnosis and Treatment in Rheumatoid Arthritis.
Zheng X, Huang J, Meng J, Wang H, Chen L, Yao J
Molecular biotechnology 2025 Oct;67(10):3975-3992
Molecular biotechnology 2025 Oct;67(10):3975-3992
S100A9 inhibition ameliorates HFpEF by modulating mitochondrial fission and oxidative stress.
Wang M, Ren B, Wu X, Guo J, Cao Y, Men L, Shi W, Zhang C, Lin L, Lv J, Li S, Huo S
International immunopharmacology 2025 Oct 10;163:115280
International immunopharmacology 2025 Oct 10;163:115280
Kang Shuai Lao Pian exerts anti-aging effects by enhancing mitochondrial oxidative metabolism.
Wang X, Zhang K, Ni J, Deng H, Zhao Z, Wang Z, Li L, Chen F, Li T, Liu L, Fan G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157376
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157376
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
Yang S, Yan L, Chen L, Su G, Yang L, Gong L, Liu L
Pharmacological research 2025 May;215:107731
Pharmacological research 2025 May;215:107731
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
Sun N, Barta H, Chaudhuri S, Chen K, Jin J, Luo H, Yang M, Krigman J, Zhang R, Sanghvi S, Sekine S, Sanders H, Kolonay D, Patel M, Baskin K, Singh H, Zhang P, Xin G, Finkel T
Nature communications 2025 Jul 1;16(1):5465
Nature communications 2025 Jul 1;16(1):5465
Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3.
Dong Q, Niu W, Mu M, Ye C, Wu P, Hu S, Niu C
Molecular and cellular biochemistry 2025 Jan;480(1):355-369
Molecular and cellular biochemistry 2025 Jan;480(1):355-369
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.
Chen W, Yang W, Meng B, Wang X, Duan H, Xu Q, Li H
Journal of orthopaedic surgery and research 2025 Jan 10;20(1):30
Journal of orthopaedic surgery and research 2025 Jan 10;20(1):30
Regulation of lactate accumulation in bovine mammary epithelial cells by LPS-induced HIF-1α/MCT1 pathway.
Cheng X, Jiang Y, Zhao X, Ma N, Shen X
Microbial pathogenesis 2025 Feb;199:107261
Microbial pathogenesis 2025 Feb;199:107261
FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice.
Zhang K, Gan J, Wang B, Lei W, Zhen D, Yang J, Wang N, Wen C, Gao X, Li X, Xu A, Liu X, Li Y, Wu F, Lin Z
Nature communications 2025 Feb 15;16(1):1661
Nature communications 2025 Feb 15;16(1):1661
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation.
Ebeid C, Rump A, Tian C, Mamidi A, De Arcangelis A, Gradwohl G, Semb H
EMBO reports 2025 Dec;26(23):5877-5904
EMBO reports 2025 Dec;26(23):5877-5904
Substrate stiffness-dependent metabolic reprogramming of iPSC-derived cardiomyocytes on physiological PDMS polymers.
Patel L, Marzullo BP, Barlow J, Rana H, Azad AJ, Thomas P, Tennant DA, Gehmlich K
Metabolic engineering communications 2025 Dec;21:e00266
Metabolic engineering communications 2025 Dec;21:e00266
PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages.
Dong S, Ma L, Shen C, Gu R, Li X, Xiao Y, Zhao C
Journal of clinical and translational hepatology 2025 Dec 28;13(12):1046-1059
Journal of clinical and translational hepatology 2025 Dec 28;13(12):1046-1059
Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis.
Wang Y, Chen Z, Huang K, Ye K, He S, Xu Y, Chen H
Arthritis research & therapy 2025 Aug 20;27(1):166
Arthritis research & therapy 2025 Aug 20;27(1):166
Cross-Organ Proteome Analysis Reveals Changes in Protein Expression Related With Glucose and Amino Acid Metabolism in Muscles and Hearts of Torpid Mice.
Miyamoto H, Ito S, Ogata S, Shimojima R, Sato K, Kadowaki T, Tokunaga A, Sato K, Kodama Y, Nakashima MN, Nishida K, Nakashima M, Ohtsuki S, Ohyama K
Cell biochemistry and function 2025 Apr;43(4):e70076
Cell biochemistry and function 2025 Apr;43(4):e70076
EGR2 promotes liver cancer metastasis by enhancing IL-8 expression through transcription regulation of PDK4 in M2 macrophages.
Wei S, Xu G, Zhao S, Zhang C, Feng Y, Yang W, Lu R, Zhou J, Ma Y
International immunopharmacology 2025 Apr 24;153:114484
International immunopharmacology 2025 Apr 24;153:114484
Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy.
Yue R, Yan Z, Zha H, Xia Y, Huang H, Li H, Ding M, Abdullah MMH, Hu B, Shi L, Zhu J, Song Z
International immunopharmacology 2025 Apr 16;152:114342
International immunopharmacology 2025 Apr 16;152:114342
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states.
Trinh B, Rasmussen SJ, Brøgger-Jensen ME, Engelhard CA, Lund A, Tavanez AR, Vassilieva A, Janum S, Iepsen UW, Kiens B, Møller K, Pedersen BK, Van Hall G, Ellingsgaard H
Cell reports. Medicine 2025 Apr 15;6(4):102042
Cell reports. Medicine 2025 Apr 15;6(4):102042
Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein.
Hansen D, Jensen JER, Andersen CAT, Jakobsgaard PR, Havelund J, Lauritsen L, Mandacaru S, Siersbaek M, Shackleton OL, Inoue H, Brewer JR, Schwabe RF, Blagoev B, Færgeman NJ, Salmi M, Ravnskjaer K
Cell metabolism 2025 Apr 1;37(4):971-986.e8
Cell metabolism 2025 Apr 1;37(4):971-986.e8
Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes.
Kita A, Araki R, Yabe T
Biological & pharmaceutical bulletin 2024;47(9):1542-1549
Biological & pharmaceutical bulletin 2024;47(9):1542-1549
A novel genetic model provides a unique perspective on the relationship between postexercise glycogen concentration and increases in the abundance of key metabolic proteins after acute exercise.
Kwak SE, Zheng A, Arias EB, Wang H, Pan X, Yue Y, Duan D, Cartee GD
PloS one 2024;19(1):e0295964
PloS one 2024;19(1):e0295964
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4.
He W, Ding C, Lin T, Wang B, Wang W, Deng Z, Jin T, Shang Y, Zheng D, Bai T, Zhang M, Li R, Jin J, He Q
Theranostics 2024;14(19):7534-7553
Theranostics 2024;14(19):7534-7553
G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.
Si Y, Ou H, Jin X, Gu M, Sheng S, Peng W, Yang D, Zhan X, Zhang L, Yu Q, Liu X, Liu Y
Free radical biology & medicine 2024 Sep;222:478-492
Free radical biology & medicine 2024 Sep;222:478-492
PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury.
Tian S, Yang X, Lin Y, Li X, Zhou S, Yu P, Zhao Y
Cellular signalling 2024 Sep;121:111282
Cellular signalling 2024 Sep;121:111282
Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice.
Park SY, Jung SR, Kim JY, Kim YW, Sung HK, Park SY, Doh KO, Koh JH
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C619-C633
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C619-C633
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC
Cell research 2024 Oct;34(10):683-706
Cell research 2024 Oct;34(10):683-706
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Li H, Xia Y, Zha H, Zhang Y, Shi L, Wang J, Huang H, Yue R, Hu B, Zhu J, Song Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock.
Sun J, Zhang Y, Adams JA, Higgins CB, Kelly SC, Zhang H, Cho KY, Johnson UG, Swarts BM, Wada SI, Patti GJ, Shriver LP, Finck BN, Herzog ED, DeBosch BJ
Cell reports 2024 Oct 22;43(10):114865
Cell reports 2024 Oct 22;43(10):114865
NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Wang J, Zhao R, Xu S, Zhou XY, Cai K, Chen YL, Zhou ZY, Sun X, Shi Y, Wang F, Gui YH, Tao H, Zhao JY
Nature communications 2024 Nov 16;15(1):9945
Nature communications 2024 Nov 16;15(1):9945
Stevioside Ameliorates Palmitic Acid-Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes.
Zhang C, Li S, Li L, Wang R, Luo S, Li G
Endocrinology, diabetes & metabolism 2024 May;7(3):e00482
Endocrinology, diabetes & metabolism 2024 May;7(3):e00482
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
Anegawa T, Sasaki KI, Ishizaki Y, Negoto S, Oryoji A, Nakamura E, Otsuka H, Hiromatsu S, Fukumoto Y, Tayama E
The Kurume medical journal 2024 May 14;69(3.4):167-174
The Kurume medical journal 2024 May 14;69(3.4):167-174
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Yang C, Xing S, Wei X, Lu J, Zhao G, Ma X, Dai Z, Liang X, Huang W, Liu Y, Jiang X, Zhu D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Inhibition of glycolysis enhances the efficacy of immunotherapy via PDK-mediated upregulation of PD-L1.
Zhang R, Mao G, Tang Y, Li C, Gao Y, Nie W, Song T, Liu S, Zhang P, Tao K, Li W
Cancer immunology, immunotherapy : CII 2024 Jun 4;73(8):151
Cancer immunology, immunotherapy : CII 2024 Jun 4;73(8):151
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M
Cell metabolism 2024 Jun 4;36(6):1371-1393.e7
Cell metabolism 2024 Jun 4;36(6):1371-1393.e7
Eicosapentaenoic acid increases proportion of type 1 muscle fibers through PPARδ and AMPK pathways in rats.
Komiya Y, Sakazaki Y, Goto T, Kawabata F, Suzuki T, Sato Y, Sawano S, Nakamura M, Tatsumi R, Ikeuchi Y, Arihara K, Mizunoya W
iScience 2024 Jun 21;27(6):109816
iScience 2024 Jun 21;27(6):109816
Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.
Komiya Y, Iseki S, Ochiai M, Takahashi Y, Yokoyama I, Suzuki T, Tatsumi R, Sawano S, Mizunoya W, Arihara K
Scientific reports 2024 Jan 8;14(1):755
Scientific reports 2024 Jan 8;14(1):755
Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation.
Chen J, Ren T, Xie L, Hu H, Li X, Maitusong M, Zhou X, Hu W, Xu D, Qian Y, Cheng S, Yu K, Wang JA, Liu X
Nature communications 2024 Jan 16;15(1):557
Nature communications 2024 Jan 16;15(1):557
Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation.
Chen T, Xie Q, Tan B, Yi Q, Xiang H, Wang R, Zhou Q, He B, Tian J, Zhu J, Xu H
Inflammation 2024 Aug;47(4):1356-1370
Inflammation 2024 Aug;47(4):1356-1370
Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice.
Flora GD, Ghatge M, Nayak MK, Barbhuyan T, Kumskova M, Chauhan AK
Blood advances 2024 Aug 13;8(15):3906-3913
Blood advances 2024 Aug 13;8(15):3906-3913
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340
The Journal of physiology 2024 Apr;602(7):1313-1340
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy.
Su Q, Huang W, Huang Y, Dai R, Chang C, Li QY, Liu H, Li Z, Zhao Y, Wu Q, Pan DG
Cardiovascular diabetology 2024 Apr 25;23(1):139
Cardiovascular diabetology 2024 Apr 25;23(1):139
A tryptophan-derived uremic metabolite/Ahr/Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease.
Thome T, Vugman NA, Stone LE, Wimberly K, Scali ST, Ryan TE
JCI insight 2024 Apr 23;9(10)
JCI insight 2024 Apr 23;9(10)
Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy.
Chen T, Ye L, Zhu J, Tan B, Yi Q, Sun Y, Xie Q, Xiang H, Wang R, Tian J, Xu H
The Journal of infectious diseases 2024 Apr 12;229(4):1178-1188
The Journal of infectious diseases 2024 Apr 12;229(4):1178-1188
Identification of PDK4 as Hub Gene for Diabetic Nephropathy Using Co-Expression Network Analysis.
Han Y, Jin L, Wang L, Wei L, Tu C
Kidney & blood pressure research 2023;48(1):522-534
Kidney & blood pressure research 2023;48(1):522-534
Prognostic value of autophagy-related genes based on single-cell RNA-sequencing in colorectal cancer.
Luo Y, Deng X, Liao W, Huang Y, Lu C
Frontiers in genetics 2023;14:1109683
Frontiers in genetics 2023;14:1109683
PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer.
Yamashita M, Kumazoe M, Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H
Biochemical and biophysical research communications 2023 Sep 10;672:154-160
Biochemical and biophysical research communications 2023 Sep 10;672:154-160
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T
Nature 2023 Oct;622(7983):619-626
Nature 2023 Oct;622(7983):619-626
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Ma Z, Mo R, Yang P, Ding Y, Zhang H, Dong Z, Chen Y, Tan Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.
Armour SL, Frueh A, Chibalina MV, Dou H, Argemi-Muntadas L, Hamilton A, Katzilieris-Petras G, Carmeliet P, Davies B, Moritz T, Eliasson L, Rorsman P, Knudsen JG
Diabetes 2023 Oct 1;72(10):1446-1459
Diabetes 2023 Oct 1;72(10):1446-1459
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
Low-Carbohydrate Diet Modulates Glucose-Lipid Utilization in Skeletal Muscle of Diabetic Mice.
Li Y, Yang Z, Wang Y, Fan M, Nie C, Xue L, Wang L, Qian H
Nutrients 2023 Mar 21;15(6)
Nutrients 2023 Mar 21;15(6)
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Wu J, Luo J, He Q, Xia Y, Tian H, Zhu L, Li C, Loor JJ
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Acetate controls endothelial-to-mesenchymal transition.
Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M
Cell metabolism 2023 Jul 11;35(7):1163-1178.e10
Cell metabolism 2023 Jul 11;35(7):1163-1178.e10
1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation.
Zhu H, Ma H, Dong N, Wu M, Li D, Liu L, Shi Q, Ju X
BMC cancer 2023 Feb 6;23(1):122
BMC cancer 2023 Feb 6;23(1):122
Astrocytic FoxO1 in the hypothalamus regulates metabolic homeostasis by coordinating neuropeptide Y neuron activity.
Doan KV, Tran LT, Yang DJ, Ha TTA, Mai TD, Kim SK, DePinho RA, Shin DM, Choi YH, Kim KW
Glia 2023 Dec;71(12):2735-2752
Glia 2023 Dec;71(12):2735-2752
Distinct Transcriptional Responses of Skeletal Muscle to Short-Term Cold Exposure in Tibetan Pigs and Bama Pigs.
Yang C, Cao C, Liu J, Zhao Y, Pan J, Tao C, Wang Y
International journal of molecular sciences 2023 Apr 18;24(8)
International journal of molecular sciences 2023 Apr 18;24(8)
Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1α promotes Osteosarcoma Progression and Glycolysis Metabolism.
Shen S, Xu Y, Gong Z, Yao T, Qiao D, Huang Y, Zhang Z, Gao J, Ni H, Jin Z, Zhu Y, Wu H, Wang Q, Fang X, Huang K, Ma J
Aging and disease 2023 Apr 1;14(2):529-547
Aging and disease 2023 Apr 1;14(2):529-547
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Wang M, Zhao M, Yu J, Xu Y, Zhang J, Liu J, Zheng Z, Ye J, Wang Z, Ye D, Feng Y, Xu S, Pan W, Wei C, Wan J
Frontiers in cardiovascular medicine 2022;9:727474
Frontiers in cardiovascular medicine 2022;9:727474
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Zhang H, Yan M, Liu T, Wei P, Chai N, Li L, Wang J, Yu X, Lin Y, Qiu B, Zhao Y
Frontiers in cell and developmental biology 2022;10:840389
Frontiers in cell and developmental biology 2022;10:840389
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Ni J, Liu Z, Jiang M, Li L, Deng J, Wang X, Su J, Zhu Y, He F, Mao J, Gao X, Fan G
Journal of ginseng research 2022 Mar;46(2):235-247
Journal of ginseng research 2022 Mar;46(2):235-247
Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice.
Shimizu J, Kawano F
The Journal of physiology 2022 Jul;600(14):3331-3353
The Journal of physiology 2022 Jul;600(14):3331-3353
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.
Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D
Science translational medicine 2022 Jan 26;14(629):eabh2548
Science translational medicine 2022 Jan 26;14(629):eabh2548
Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1α axis and insulin sensitivity.
Luo Y, Zhou W, Li R, Limbu SM, Qiao F, Chen L, Zhang M, Du ZY
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Dec;11:25-37
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Dec;11:25-37
Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study of Mitochondrial Proteome.
Shimada BK, Boyman L, Huang W, Zhu J, Yang Y, Chen F, Kane MA, Yadava N, Zou L, Lederer WJ, Polster BM, Chao W
Shock (Augusta, Ga.) 2022 Apr 1;57(4):553-564
Shock (Augusta, Ga.) 2022 Apr 1;57(4):553-564
Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.
Shen Y, Wang X, Yuan R, Pan X, Yang X, Cai J, Li Y, Yin A, Xiao Q, Ji Q, Li Y, He B, Shen L
Journal of molecular and cellular cardiology 2021 Oct;159:91-104
Journal of molecular and cellular cardiology 2021 Oct;159:91-104
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Christianto A, Baba T, Takahashi F, Inui K, Inoue M, Suyama M, Ono Y, Ohkawa Y, Morohashi KI
Communications biology 2021 Nov 4;4(1):1264
Communications biology 2021 Nov 4;4(1):1264
Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells.
Qi W, Xu Q, Xu Y, Wang Z, Yang L, Guo S, Shi Y, Zhao T, Zhou L, Ye L
Ecotoxicology and environmental safety 2021 Jan 15;208:111472
Ecotoxicology and environmental safety 2021 Jan 15;208:111472
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Song X, Liu J, Kuang F, Chen X, Zeh HJ 3rd, Kang R, Kroemer G, Xie Y, Tang D
Cell reports 2021 Feb 23;34(8):108767
Cell reports 2021 Feb 23;34(8):108767
Effects of Dietary Fat Restriction on Endurance Training-induced Metabolic Adaptations in Rat Skeletal Muscle.
Karasawa T, Kondo S, Fukazawa A, Koike A, Tsutsui M, Terada S
Journal of oleo science 2021 Feb 1;70(2):253-262
Journal of oleo science 2021 Feb 1;70(2):253-262
Dietary Olive Oil Intake Improves Running Endurance with Intramuscular Triacylglycerol Accumulation in Mice.
Komiya Y, Sugiyama M, Ochiai M, Osawa N, Adachi Y, Iseki S, Arihara K
Nutrients 2021 Apr 1;13(4)
Nutrients 2021 Apr 1;13(4)
Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia.
Tanaka K, Watanabe T, Ozawa J, Ito M, Nagano N, Arai Y, Miyake F, Matsumura S, Kobayashi S, Itakura R, Namba F
PloS one 2020;15(9):e0238604
PloS one 2020;15(9):e0238604
Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells.
Qin YJ, Lin TY, Lin XL, Liu Y, Zhao WT, Li XY, Lian M, Chen HW, Li YL, Zhang XL, Xiao D, Jia JS, Sun Y
Journal of Cancer 2020;11(15):4397-4405
Journal of Cancer 2020;11(15):4397-4405
Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).
Lai N, Fealy CE, Kummitha CM, Cabras S, Kirwan JP, Hoppel CL
Frontiers in physiology 2020;11:677
Frontiers in physiology 2020;11:677
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119
Nature cell biology 2020 Jan;22(1):108-119
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Jonus HC, Byrnes CC, Kim J, Valle ML, Bartlett MG, Said HM, Zastre JA
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
Chen C, Luo F, Wu P, Huang Y, Das A, Chen S, Chen J, Hu X, Li F, Fang Z, Zhou S
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat JP, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L
Molecular systems biology 2020 Apr;16(4):e9247
Molecular systems biology 2020 Apr;16(4):e9247
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Fukazawa A, Koike A, Karasawa T, Tsutsui M, Kondo S, Terada S
Nutrients 2020 Apr 30;12(5)
Nutrients 2020 Apr 30;12(5)
Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer.
Wang J, Qian Y, Gao M
Cancer management and research 2019;11:251-262
Cancer management and research 2019;11:251-262
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.
Li Y, Pan H, Zhang X, Wang H, Liu S, Zhang H, Qian H, Wang L, Ying H
Journal of agricultural and food chemistry 2019 Apr 24;67(16):4483-4492
Journal of agricultural and food chemistry 2019 Apr 24;67(16):4483-4492
Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.
Fekir K, Dubois-Pot-Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, Morel F, Fromenty B, Musso O, Cabillic F, Corlu A
Cancer research 2019 Apr 15;79(8):1869-1883
Cancer research 2019 Apr 15;79(8):1869-1883
Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells.
Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, Zhang H, Xu M, Rao Z, Wang L, Ying H
International journal of biological macromolecules 2018 Oct 1;117:287-293
International journal of biological macromolecules 2018 Oct 1;117:287-293
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Zhang P, Song Y, Sun Y, Li X, Chen L, Yang L, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H
Scientific reports 2017 Aug 16;7(1):8474
Scientific reports 2017 Aug 16;7(1):8474
Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia.
Li X, Liu Y, Ma H, Guan Y, Cao Y, Tian Y, Zhang Y
Frontiers in physiology 2016;7:219
Frontiers in physiology 2016;7:219
MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Lin X, Qin Y, Jia J, Lin T, Lin X, Chen L, Zeng H, Han Y, Wu L, Huang S, Wang M, Huang S, Xie R, Liang L, Liu Y, Liu R, Zhang T, Li J, Wang S, Sun P, Huang W, Yao K, Xu K, Du T, Xiao D
PLoS genetics 2016 Oct;12(10):e1006308
PLoS genetics 2016 Oct;12(10):e1006308
Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats.
Jiang X, Ma H, Li C, Cao Y, Wang Y, Zhang Y, Liu Y
Pediatric research 2016 Jul;80(1):128-35
Pediatric research 2016 Jul;80(1):128-35
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Kemmerer M, Finkernagel F, Cavalcante MF, Abdalla DS, Müller R, Brüne B, Namgaladze D
PloS one 2015;10(6):e0130893
PloS one 2015;10(6):e0130893
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.
Strand DW, Jiang M, Murphy TA, Yi Y, Konvinse KC, Franco OE, Wang Y, Young JD, Hayward SW
Cell death & disease 2012 Aug 9;3(8):e361
Cell death & disease 2012 Aug 9;3(8):e361
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 12949-1-AP(PDK4 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 12949-1-AP(PDK4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDK4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK4. This antibody recognizes human,mouse,rat antigen. The PDK4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
