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- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 13990-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13990-1-AP, RRID:AB_2225833
- Product name
- GRK2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GRK2 antibody (Cat. #13990-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction.
GRK phosphorylation drives β-arrestin-independent internalization of chemokine receptor CXCR5.
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
Microcystin-LR Exposure Damages Neurons by Inducing α-Syn Aggregation via MAPK4/GATA2/SNCA and PP2A/GRKs Pathways.
SNX9 family mediates βarrestin-independent GPCR endocytosis.
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis.
Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells.
Paeoniflorin-6'-o-benzene sulfonate ameliorates the progression of adjuvant-induced arthritis by inhibiting the interaction between Ahr and GRK2 of fibroblast-like synoviocytes.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia.
Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
The influence of TNF-α and Ang II on the proliferation, migration and invasion of HepG2 cells by regulating the expression of GRK2.
Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.
si-RNA-Mediated Silencing of ADRBK1 Gene Attenuates Breast Cancer Cell Proliferation.
Kayki Mutlu G, Kereliuk SM, Hoteit M, Chuprun JK, Mendes U, Olgar Y, Koch WJ
Cells 2026 Mar 4;15(5)
Cells 2026 Mar 4;15(5)
GRK phosphorylation drives β-arrestin-independent internalization of chemokine receptor CXCR5.
Crecelius JM, Zhuo Y, Manz AR, Drube J, Schulz S, Hoffmann C, Marchese A
The Journal of biological chemistry 2026 Feb;302(2):111114
The Journal of biological chemistry 2026 Feb;302(2):111114
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
Yang XZ, Zhang WK, Zhu ZQ, Zhao W, Luo LL, Wang LP, Zhao YJ, Chang Y, Wei W
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
Microcystin-LR Exposure Damages Neurons by Inducing α-Syn Aggregation via MAPK4/GATA2/SNCA and PP2A/GRKs Pathways.
Yan M, Wu H, Wu T, Wang Y, Su C, Li D, Han X
Molecular neurobiology 2025 May;62(5):6195-6211
Molecular neurobiology 2025 May;62(5):6195-6211
SNX9 family mediates βarrestin-independent GPCR endocytosis.
Robleto VL, Zhuo Y, Crecelius JM, Benzow S, Marchese A
Communications biology 2024 Nov 7;7(1):1455
Communications biology 2024 Nov 7;7(1):1455
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
Zhang JJ, Song CG, Wang M, Zhang GQ, Wang B, Chen X, Lin P, Zhu YM, Sun ZC, Wang YZ, Jiang JL, Li L, Yang XM, Chen ZN
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
Lin XT, Zhang J, Liu ZY, Wu D, Fang L, Li CM, Yu HQ, Xie CM
Cell reports 2023 Jul 25;42(7):112812
Cell reports 2023 Jul 25;42(7):112812
Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis.
Mo S, Guo J, Ye T, Zhang X, Zeng J, Xu Y, Peng B, Dai Y, Xiao W, Zhang P, Deng G, Xu D, Long X, Cai Y, Chen X
mBio 2022 Oct 26;13(5):e0200422
mBio 2022 Oct 26;13(5):e0200422
Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells.
Zhou Q, Lin W, Wang C, Sun F, Ju S, Chen Q, Wang Y, Chen Y, Li H, Wang L, Hu Z, Jin H, Wang X, Sun Y
Nature communications 2022 May 31;13(1):3034
Nature communications 2022 May 31;13(1):3034
Paeoniflorin-6'-o-benzene sulfonate ameliorates the progression of adjuvant-induced arthritis by inhibiting the interaction between Ahr and GRK2 of fibroblast-like synoviocytes.
Zhang BJ, Wang YY, Jia CY, Li SS, Wang XW, Xu Y, Chen AY, Xu HP, Wang C, Yang ZY, Wei W, Chang Y
International immunopharmacology 2022 Jul;108:108678
International immunopharmacology 2022 Jul;108:108678
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia.
Chen X, Sheng L, Ma J, Qi D, Li X, Wang Z, Wu Z, Wong L, Huang JH, Wu E, Ma Q, Zhang D
iScience 2022 Jan 21;25(1):103647
iScience 2022 Jan 21;25(1):103647
Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension.
Sun X, Zhou M, Wen G, Huang Y, Wu J, Peng L, Jiang W, Yuan H, Lu Y, Cai J
Journal of the American Heart Association 2021 Jan 5;10(1):e016364
Journal of the American Heart Association 2021 Jan 5;10(1):e016364
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
The influence of TNF-α and Ang II on the proliferation, migration and invasion of HepG2 cells by regulating the expression of GRK2.
Xu ZW, Yan SX, Wu HX, Chen JY, Zhang Y, Li Y, Wei W
Cancer chemotherapy and pharmacology 2017 Apr;79(4):747-758
Cancer chemotherapy and pharmacology 2017 Apr;79(4):747-758
Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.
Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY, Sun JP
Nature communications 2015 Sep 8;6:8202
Nature communications 2015 Sep 8;6:8202
si-RNA-Mediated Silencing of ADRBK1 Gene Attenuates Breast Cancer Cell Proliferation.
Zhang C, Chen X, Li Y, S W A H, Wu J, Shi X, Liu X, Kim S
Cancer biotherapy & radiopharmaceuticals 2014 Oct;29(8):303-9
Cancer biotherapy & radiopharmaceuticals 2014 Oct;29(8):303-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13990-1-AP(ADRBK1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13990-1-AP(ADRBK1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13990-1-AP(ADRBK1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GRK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GRK2. This antibody recognizes human antigen. The GRK2 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
