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- Antibody Data
- Antigen structure
- References [116]
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- Western blot [1]
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- Immunoprecipitation [1]
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- Product number
- 14528-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14528-1-AP, RRID:AB_2303727
- Product name
- TOM70 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOM70 antibody (Cat. #14528-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Magnetic Metal-Organic Framework (MOF)-Mediated Precision Capture of Mitochondria Reveals Subcellular Metabolic and Lipid Remodeling of Crabtree Effect in Yeast.
27-Hydroxycholesterol inhibits muscle cell viability via mitochondrial dysfunction: Protective role of ROS-induced HIF-1α.
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Investigating the Potential Role of Capsaicin in Facilitating the Spread of Coxsackievirus B3 via Extracellular Vesicles.
Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus.
Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.
The Mislocalization of TDP-43 to Mitochondria Impairs Myotube Maturation.
Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancer.
Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection.
AAV9-mediated gene therapy restores liver function in the MEGDHEL mouse model.
Principles of cotranslational mitochondrial protein import.
Identification of novel NDUFA3 variants in a patient with mitochondrial disorders.
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.
Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.
The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function.
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis.
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Mitochondrial proteostasis regulated by CRL5(Ozz) and Alix modulates skeletal muscle metabolism and fiber type.
RNA triggers chronic stress during neuronal aging.
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue.
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease.
Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice.
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration.
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Full-length GSDME mediates pyroptosis independent from cleavage.
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Geranylgeranylated SCF(FBXO10) regulates selective outer mitochondrial membrane proteostasis and function.
Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells.
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder.
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Biallelic variants in the NDUFAF6 cause mitochondrial respiratory complex assembly defects associated with Leigh syndrome in probands.
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Investigating the potential role of capsaicin in facilitating the spread of coxsackievirus B3 via extracellular vesicles.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
Geranylgeranylated-SCF(FBXO10) Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function.
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells.
CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
The Rab5 effector FERRY links early endosomes with mRNA localization.
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency.
Switching ubiquitous and muscle-specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine-tunes complex IV activity.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy.
ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
MTCH2 is a mitochondrial outer membrane protein insertase.
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy.
Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice.
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells.
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
A membrane arm of mitochondrial complex I sufficient to promote respirasome formation.
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover.
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Antiviral Effects of Menthol on Coxsackievirus B.
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.
EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex.
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Efficient proximity labeling in living cells and organisms with TurboID.
Yap regulates mitochondrial structural remodeling during myoblast differentiation.
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
GRSF1 suppresses cell senescence.
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes.
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Directed evolution of APEX2 for electron microscopy and proximity labeling.
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Du T, Li T, Chen F, Huang D, Han R, Zhao C, Liu X, Shi X, Xu G
Analytical chemistry 2026 May 19;98(19):14086-14095
Analytical chemistry 2026 May 19;98(19):14086-14095
27-Hydroxycholesterol inhibits muscle cell viability via mitochondrial dysfunction: Protective role of ROS-induced HIF-1α.
Azamov B, Shim WS, Lee C, Kang Y, Jo Y, Rethineswaran VK, Muradillaeva S, Hwang S, Ryu S, Bae SS, Kim JH, Moon HY, Song C, Shin JH, Hong C, Lee KM, Song P
Free radical biology & medicine 2026 Jun;249:393-408
Free radical biology & medicine 2026 Jun;249:393-408
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105
The EMBO journal 2026 Jan;45(1):64-105
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Wang J, Yu W, Cai S, Wei H, Peng B, Qian J, Chen Y, Zheng F, Jiang H, Xie Q, Zhou H, Fang H, Lyu J
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Investigating the Potential Role of Capsaicin in Facilitating the Spread of Coxsackievirus B3 via Extracellular Vesicles.
Chatterjee S, Kordbacheh R, Tilley H, Briordy D, Waldron RT, Cutts WD, Aleman J, Cook A, Dhanji R, Wong LR, Pandol SJ, Kim BJ, Fairweather D, Sin J
International journal of molecular sciences 2026 Jan 9;27(2)
International journal of molecular sciences 2026 Jan 9;27(2)
Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus.
Gao XN, Shu HB, Li M
Pathogens (Basel, Switzerland) 2026 Jan 9;15(1)
Pathogens (Basel, Switzerland) 2026 Jan 9;15(1)
Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.
Yang M, Oatley MJ, Miao D, Maddison LA, Oatley JM
Cell reports 2026 Jan 27;45(1):116731
Cell reports 2026 Jan 27;45(1):116731
The Mislocalization of TDP-43 to Mitochondria Impairs Myotube Maturation.
Wan Y, Yu Z, Yang J, Zhang W, Yu M, Meng L, Wang Z, Yuan Y, Ruan L, Deng J, Wang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71603
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71603
Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancer.
Berner MJ, Wall SW, Baek ML, Lane A, Greer AS, Wang K, Dobrolecki LE, Strope I, Zhu Q, Zhang B, Lei JT, Lewis MT, Echeverria GV
bioRxiv : the preprint server for biology 2026 Apr 18;
bioRxiv : the preprint server for biology 2026 Apr 18;
Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection.
Oh SJ, Kim YY, Ma R, Choi ST, Choi SM, Cho JH, Hur JY, Yoo Y, Han K, Park H, Yun J, Shin OS
Theranostics 2025;15(11):4890-4908
Theranostics 2025;15(11):4890-4908
AAV9-mediated gene therapy restores liver function in the MEGDHEL mouse model.
Wei T, Lin Y, Ouyang W, Lei Y, Yang X, Chen L, He X, Fang Q, Zheng X, Tong H, Tu B, Zeng J, Lyu J, Du M, Gui S
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120014
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120014
Principles of cotranslational mitochondrial protein import.
Zhu Z, Mallik S, Stevens TA, Huang R, Levy ED, Shan SO
Cell 2025 Oct 2;188(20):5605-5617.e14
Cell 2025 Oct 2;188(20):5605-5617.e14
Identification of novel NDUFA3 variants in a patient with mitochondrial disorders.
Sun Y, Wei X, Xiao B, Luo Y, Wang Y, Liu R, Zhan Y, Ye X, Cai X, Xu S, Lyu J, Fang H, Yu Y
Pediatric research 2025 Oct 2;
Pediatric research 2025 Oct 2;
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.
Wang B, Han X, Lin X, Wang J, You C, Chen K, Chen Y, Meng F, Jiang H, Zheng F, Zhang Y, Lyu J, Bai Y, Qu X, Zhou D, Jiang M, Cui W, Lyu J, Fang H
Nature communications 2025 Nov 5;16(1):9772
Nature communications 2025 Nov 5;16(1):9772
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Chen J, Yap MC, Bassot A, Pascual DM, Makio T, Zimmermann J, Mast H, Bhat R, Fleury SG, Fan Y, Buzatto AZ, Moore J, Ballanyi K, Li L, Overduin M, Lemieux MJ, Lemieux H, Mancini GMS, Morgan B, Marcogliese PC, Simmen T
Cell reports 2025 Nov 25;44(11):116486
Cell reports 2025 Nov 25;44(11):116486
Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.
Kozhukhar N, Bai Y, Alexeyev MF
Journal of molecular biology 2025 Nov 1;437(21):169433
Journal of molecular biology 2025 Nov 1;437(21):169433
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.
Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi JM, Bennett CF, Lamas-Paz A, Sohn JH, Jackson TD, Jedrychowski M, Gygi SP, Kajimura S, Schmoker A, Jeon H, Eck MJ, Puigserver P
Nature cell biology 2025 Jan;27(1):130-140
Nature cell biology 2025 Jan;27(1):130-140
Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.
Zheng J, Chen J, Cao Z, Wu K, Wang J, Guo Y, Zhuang M
Developmental cell 2025 Jan 6;60(1):30-39.e3
Developmental cell 2025 Jan 6;60(1):30-39.e3
The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.
Kim BR, Rauckhorst AJ, Chimenti MS, Rehman T, Keen HL, Karp PH, Taylor EB, Welsh MJ
Science advances 2025 Jan 24;11(4):eadr2282
Science advances 2025 Jan 24;11(4):eadr2282
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Gao X, Huang D, Liu Y, Zhang G, Zheng X, Guan B, Chen A, Wu J, Luo SM, Liu Z, Chen L, Liu X, Jin J, Yin X, Sun Z, Zhang Y, Lu M, Zhang G, Liu W, Liu L
Cell death & disease 2025 Feb 3;16(1):63
Cell death & disease 2025 Feb 3;16(1):63
Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.
Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function.
Saunders RA, Allen WE, Pan X, Sandhu J, Lu J, Lau TK, Smolyar K, Sullivan ZA, Dulac C, Weissman JS, Zhuang X
bioRxiv : the preprint server for biology 2025 Feb 17;
bioRxiv : the preprint server for biology 2025 Feb 17;
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.
Gao J, Ding M, Xiyang Y, Qin S, Shukla D, Xu J, Miyagi M, Fujioka H, Liang J, Wang X
Journal of immunology (Baltimore, Md. : 1950) 2025 Feb 1;214(2):238-252
Journal of immunology (Baltimore, Md. : 1950) 2025 Feb 1;214(2):238-252
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis.
Jiang A, Wang L, Liu X, Li J, Wang H, Wu S, Bao W
Redox report : communications in free radical research 2025 Dec;30(1):2536400
Redox report : communications in free radical research 2025 Dec;30(1):2536400
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Dong C, Finigan A, Figg N, Jenkins B, Koulman A, Chowdhury SR, Tricolici AM, Lambert J, Oc S, Jørgensen HF, Prudent J, Murphy MP, Bennett M, Yu E
Nature communications 2025 Dec 4;16(1):10909
Nature communications 2025 Dec 4;16(1):10909
Mitochondrial proteostasis regulated by CRL5(Ozz) and Alix modulates skeletal muscle metabolism and fiber type.
Campos Y, Palacios G, Gomero E, van de Vlekkert D, Venkataraman K, John J, Weesner JA, Wakefield R, Qiu X, Rodriguez-Enriquez R, Rockfield S, Demmers J, Opferman JT, Robinson C, Khairy K, Bertorini T, Grosveld GC, d'Azzo A
Communications biology 2025 Dec 22;9(1)
Communications biology 2025 Dec 22;9(1)
RNA triggers chronic stress during neuronal aging.
Rhine K, Epstein E, Carlson NM, Ge X, Mizrahi O, Kamat A, Hermann A, Brothers WR, Ravits J, Bennett EJ, Pekkurnaz G, Yeo GW
bioRxiv : the preprint server for biology 2025 Aug 5;
bioRxiv : the preprint server for biology 2025 Aug 5;
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue.
Saunders RA, Allen WE, Pan X, Sandhu J, Lu J, Lau TK, Smolyar K, Sullivan ZA, Dulac C, Weissman JS, Zhuang X
Cell 2025 Aug 21;188(17):4790-4809.e22
Cell 2025 Aug 21;188(17):4790-4809.e22
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease.
Liu Q, Wang X, Fang ZT, Zhao JN, Rui XX, Zhang BG, He Y, Liu RJ, Chen J, Chai GS, Liu GP
Autophagy 2025 Apr;21(4):807-826
Autophagy 2025 Apr;21(4):807-826
Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice.
Müller M, Schubert T, Welke C, Maske T, Patschkowski T, Donhauser E, Heinen-Weiler J, Hormann FL, Heiles S, Schulz TJ, Lengenfelder LA, Landwehrjohann L, Vogt ET, Stratmann B, Hense J, Lüdtke S, Düfer M, Tolstik E, Dierks J, Lorenz K, Huxohl T, Reil JC, Sequeira V, Schopfer FJ, Freeman BA, Rudolph V, Schlomann U, Klinke A
Nature communications 2025 Apr 26;16(1):3933
Nature communications 2025 Apr 26;16(1):3933
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration.
Garg V, Möbius W, Heinrich R, Ruhwedel T, Perera RP, Scholz P, Ischebeck T, Salinas G, Dullin C, Göpfert MC, Engelmann J, Dosch R, Geurten BRH
Disease models & mechanisms 2025 Apr 1;18(4)
Disease models & mechanisms 2025 Apr 1;18(4)
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006
International journal of biological sciences 2024;20(10):3986-4006
Full-length GSDME mediates pyroptosis independent from cleavage.
Zhou B, Jiang ZH, Dai MR, Ai YL, Xiao L, Zhong CQ, Wu LZ, Chen QT, Chen HZ, Wu Q
Nature cell biology 2024 Sep;26(9):1545-1557
Nature cell biology 2024 Sep;26(9):1545-1557
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Raby A, Missiroli S, Sanatine P, Langui D, Pansiot J, Beaude N, Vezzana L, Saleh R, Marinello M, Laforge M, Pinton P, Buj-Bello A, Burgo A
iScience 2024 Sep 20;27(9):110683
iScience 2024 Sep 20;27(9):110683
Geranylgeranylated SCF(FBXO10) regulates selective outer mitochondrial membrane proteostasis and function.
Bhat SA, Vasi Z, Jiang L, Selvaraj S, Ferguson R, Salarvand S, Gudur A, Adhikari R, Castillo V, Ismail H, Dhabaria A, Ueberheide B, Kuchay S
Cell reports 2024 Oct 22;43(10):114783
Cell reports 2024 Oct 22;43(10):114783
Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells.
Li LG, Zhang D, Huang Q, Yan M, Chen NN, Yang Y, Xiao RC, Liu H, Han N, Qureshi AM, Hu J, Leng F, Hui YJ
Journal of cancer research and clinical oncology 2024 Oct 14;150(10):460
Journal of cancer research and clinical oncology 2024 Oct 14;150(10):460
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Bi PY, Killackey SA, Schweizer L, Arnoult D, Philpott DJ, Girardin SE
Communications biology 2024 Mar 30;7(1):391
Communications biology 2024 Mar 30;7(1):391
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.
Noble M, Chatterjee A, Sekaran T, Schwarzl T, Hentze MW
RNA (New York, N.Y.) 2024 Jun 17;30(7):839-853
RNA (New York, N.Y.) 2024 Jun 17;30(7):839-853
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder.
Yuan X, Wang Y, Li X, Zhong S, Zhou D, Lin X, Fang H, Yang Y, Wang M
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):913-926
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):913-926
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
Goldman A, Mullokandov M, Zaltsman Y, Regev L, Levin-Zaidman S, Gross A
EMBO reports 2024 Jan;25(1):45-67
EMBO reports 2024 Jan;25(1):45-67
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Sun Y, Cao Y, Wan H, Memetimin A, Cao Y, Li L, Wu C, Wang M, Chen S, Li Q, Ma Y, Dong M, Jiang H
Molecular cell 2024 Jan 18;84(2):327-344.e9
Molecular cell 2024 Jan 18;84(2):327-344.e9
Biallelic variants in the NDUFAF6 cause mitochondrial respiratory complex assembly defects associated with Leigh syndrome in probands.
Zhou Y, Zeng X, Zhang L, Yin X, Ma X, Li K, Qiu P, Lou X, Jin L, Wang Y, Yang Y, Shen T
Molecular genetics and metabolism reports 2024 Dec;41:101168
Molecular genetics and metabolism reports 2024 Dec;41:101168
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Xing Y, Ge J, Wang Y, Zhou X, Yuan Z, Lv M, Zhao M, Liu L, Gong D, Geng T, Xie K
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
Investigating the potential role of capsaicin in facilitating the spread of coxsackievirus B3 via extracellular vesicles.
Chatterjee S, Tilley H, Briordy D, Waldron RT, Kordbacheh R, Cutts WD, Cook A, Pandol SJ, Kim BJ, Fairweather D, Sin J
bioRxiv : the preprint server for biology 2024 Dec 2;
bioRxiv : the preprint server for biology 2024 Dec 2;
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Su W, Kochen Rossi J, Nuevo-Tapioles C, Chen T, Kawaler E, Branco C, Wong KK, Simeone DM, Gardner LB, Philips MR
Proceedings of the National Academy of Sciences of the United States of America 2024 Aug 13;121(33):e2401996121
Proceedings of the National Academy of Sciences of the United States of America 2024 Aug 13;121(33):e2401996121
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
Zhu Y, Akkaya KC, Ruta J, Yokoyama N, Wang C, Ruwolt M, Lima DB, Lehmann M, Liu F
Nature communications 2024 Apr 17;15(1):3290
Nature communications 2024 Apr 17;15(1):3290
Geranylgeranylated-SCF(FBXO10) Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function.
Bhat SA, Vasi Z, Jiang L, Selvaraj S, Ferguson R, Gudur A, Ismail H, Adhikari R, Dhabaria A, Ueberheide B, Kuchay S
bioRxiv : the preprint server for biology 2024 Apr 16;
bioRxiv : the preprint server for biology 2024 Apr 16;
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells.
Lee JK, Shin OS
Frontiers in immunology 2023;14:1203645
Frontiers in immunology 2023;14:1203645
CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.
Gokhale NS, Somfleth K, Thompson MG, Sam RK, Marciniak DM, Chu LH, Park M, Dvorkin S, Oberst A, Horner SM, Ong SE, Gale M Jr, Savan R
bioRxiv : the preprint server for biology 2023 Sep 25;
bioRxiv : the preprint server for biology 2023 Sep 25;
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Stewart H, Lu Y, O'Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Adewusi Y, Jungreis I, Lulla V, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Davidson AD, Edgar JR, Smith GL, Firth AE
iScience 2023 Nov 17;26(11):108080
iScience 2023 Nov 17;26(11):108080
Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.
Xu X, Wang X, Chen Q, Zheng A, Li D, Meng Z, Li X, Cai H, Li W, Huang S, Wang F
Journal of translational medicine 2023 May 6;21(1):307
Journal of translational medicine 2023 May 6;21(1):307
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W
Autophagy 2023 Jun;19(6):1711-1732
Autophagy 2023 Jun;19(6):1711-1732
The Rab5 effector FERRY links early endosomes with mRNA localization.
Schuhmacher JS, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, Seifert S, Schäfer R, Giner A, Toth-Petroczy A, Kalaidzidis Y, Bohnsack KE, Bohnsack MT, Schuman EM, Zerial M
Molecular cell 2023 Jun 1;83(11):1839-1855.e13
Molecular cell 2023 Jun 1;83(11):1839-1855.e13
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H
The EMBO journal 2023 Jul 3;42(13):e113033
The EMBO journal 2023 Jul 3;42(13):e113033
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R
iScience 2023 Jul 21;26(7):107118
iScience 2023 Jul 21;26(7):107118
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P
Nature communications 2023 Feb 27;14(1):1121
Nature communications 2023 Feb 27;14(1):1121
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Wang Z, Wei D, Bin E, Li J, Jiang K, Lv T, Mao X, Wang F, Dai H, Tang N
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency.
Zhou X, Lou X, Zhou Y, Xie Y, Han X, Dong Q, Ying X, Laurentinah MR, Zhang L, Chen Z, Li D, Fang H, Lyu J, Yang Y, Wang Y
Journal of human genetics 2023 Apr;68(4):239-246
Journal of human genetics 2023 Apr;68(4):239-246
Switching ubiquitous and muscle-specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine-tunes complex IV activity.
Ye X, Xie Y, Shi Y, Wang B, Han X, Zhou X, Pan K, Wang M, Fang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22891
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22891
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Cao X, Chen Y, Sang X, Xu S, Xie Z, Zhu Z, Wang P, Bi J, Xu L
Frontiers in aging neuroscience 2022;14:1013943
Frontiers in aging neuroscience 2022;14:1013943
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy.
Lechado-Terradas A, Schepers S, Zittlau KI, Sharma K, Ok O, Fitzgerald JC, Geimer S, Westermann B, Macek B, Kahle PJ
Autophagy reports 2022;1(1):576-602
Autophagy reports 2022;1(1):576-602
ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response.
Yildirim AD, Citir M, Dogan AE, Veli Z, Yildirim Z, Tufanli O, Traynor-Kaplan A, Schultz C, Erbay E
Journal of lipid research 2022 Oct;63(10):100279
Journal of lipid research 2022 Oct;63(10):100279
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
MTCH2 is a mitochondrial outer membrane protein insertase.
Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron 2022 Mar 16;110(6):967-976.e8
Neuron 2022 Mar 16;110(6):967-976.e8
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E
The Journal of biological chemistry 2022 Jul;298(7):102050
The Journal of biological chemistry 2022 Jul;298(7):102050
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fernández-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC
Nature communications 2022 Jan 28;13(1):557
Nature communications 2022 Jan 28;13(1):557
Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy.
Zittlau KI, Lechado-Terradas A, Nalpas N, Geisler S, Kahle PJ, Macek B
Molecular & cellular proteomics : MCP 2022 Feb;21(2):100191
Molecular & cellular proteomics : MCP 2022 Feb;21(2):100191
Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice.
Packialakshmi B, Stewart IJ, Burmeister DM, Feng Y, McDaniel DP, Chung KK, Zhou X
Physiological reports 2022 Feb;10(3):e15181
Physiological reports 2022 Feb;10(3):e15181
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF
The EMBO journal 2022 Dec 15;41(24):e112006
The EMBO journal 2022 Dec 15;41(24):e112006
TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.
Sawaged S, Mota T, Piplani H, Thakur R, Lall D, McCabe E, Seo S, Sutterwala FS, Feuer R, Gottlieb RA, Sin J
PLoS pathogens 2022 Aug;18(8):e1010350
PLoS pathogens 2022 Aug;18(8):e1010350
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin WG Jr
Science (New York, N.Y.) 2022 Aug 5;377(6606):621-629
Science (New York, N.Y.) 2022 Aug 5;377(6606):621-629
Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.
McCann KJ, Yadav M, Alishahedani ME, Freeman AF, Myles IA
PloS one 2021;16(3):e0248011
PloS one 2021;16(3):e0248011
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Taylor D, Germano J, Song Y, Hadj-Moussa H, Marek-Iannucci S, Dhanji R, Sin J, Czer LSC, Storey KB, Gottlieb RA
Cryobiology 2021 Oct;102:42-55
Cryobiology 2021 Oct;102:42-55
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells.
Hira S, Packialakshmi B, Tang E, Zhou X
Journal of physiology and biochemistry 2021 Feb;77(1):1-11
Journal of physiology and biochemistry 2021 Feb;77(1):1-11
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286
Nature cell biology 2021 Dec;23(12):1271-1286
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
A membrane arm of mitochondrial complex I sufficient to promote respirasome formation.
Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J
Cell reports 2021 Apr 13;35(2):108963
Cell reports 2021 Apr 13;35(2):108963
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover.
Germano JF, Huang C, Sin J, Song Y, Tucker KC, Taylor DJR, Saadaeijahromi H, Stotland A, Piplani H, Gottlieb RA, Mentzer RM Jr, Andres AM
Scientific reports 2020 May 19;10(1):8284
Scientific reports 2020 May 19;10(1):8284
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, Li J, Chen D, Xu P, Jia M, Zhou H, Fang H, Lyu J, Yang Y
Journal of human genetics 2020 Mar;65(3):231-240
Journal of human genetics 2020 Mar;65(3):231-240
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Scott HL, Buckner N, Fernandez-Albert F, Pedone E, Postiglione L, Shi G, Allen N, Wong LF, Magini L, Marucci L, O'Sullivan GA, Cole S, Powell J, Maycox P, Uney JB
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Phu L, Rose CM, Tea JS, Wall CE, Verschueren E, Cheung TK, Kirkpatrick DS, Bingol B
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Antiviral Effects of Menthol on Coxsackievirus B.
Taylor DJR, Hamid SM, Andres AM, Saadaeijahromi H, Piplani H, Germano JF, Song Y, Sawaged S, Feuer R, Pandol SJ, Sin J
Viruses 2020 Mar 28;12(4)
Viruses 2020 Mar 28;12(4)
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
Tsai YL, Coady TH, Lu L, Zheng D, Alland I, Tian B, Shneider NA, Manley JL
Genes & development 2020 Jun 1;34(11-12):785-805
Genes & development 2020 Jun 1;34(11-12):785-805
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.
Huang S, Wang X, Yu J, Tian Y, Yang C, Chen Y, Chen H, Ge H
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1020-C1028
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1020-C1028
EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex.
Hira S, Packialakshmi B, Zhou X
The journal of physiological sciences : JPS 2019 Sep;69(5):723-732
The journal of physiological sciences : JPS 2019 Sep;69(5):723-732
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB
Nature 2019 Nov;575(7782):380-384
Nature 2019 Nov;575(7782):380-384
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z
Nature 2019 Nov;575(7782):375-379
Nature 2019 Nov;575(7782):375-379
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
Efficient proximity labeling in living cells and organisms with TurboID.
Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY
Nature biotechnology 2018 Oct;36(9):880-887
Nature biotechnology 2018 Oct;36(9):880-887
Yap regulates mitochondrial structural remodeling during myoblast differentiation.
Huang S, Wang X, Wu X, Yu J, Li J, Huang X, Zhu C, Ge H
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C474-C484
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C474-C484
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q
Cell research 2018 Dec;28(12):1171-1185
Cell research 2018 Dec;28(12):1171-1185
GRSF1 suppresses cell senescence.
Noh JH, Kim KM, Idda ML, Martindale JL, Yang X, Abdelmohsen K, Gorospe M
Aging 2018 Aug 7;10(8):1856-1866
Aging 2018 Aug 7;10(8):1856-1866
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
Andres AM, Tucker KC, Thomas A, Taylor DJ, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM Jr, Gottlieb RA
JCI insight 2017 Feb 23;2(4):e89303
JCI insight 2017 Feb 23;2(4):e89303
Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes.
Sin J, McIntyre L, Stotland A, Feuer R, Gottlieb RA
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
Sin J, Andres AM, Taylor DJ, Weston T, Hiraumi Y, Stotland A, Kim BJ, Huang C, Doran KS, Gottlieb RA
Autophagy 2016;12(2):369-80
Autophagy 2016;12(2):369-80
Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.
Spadafora D, Kozhukhar N, Alexeyev MF
PloS one 2016;11(3):e0152705
PloS one 2016;11(3):e0152705
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M
Molecular biology of the cell 2016 Jan 15;27(2):349-59
Molecular biology of the cell 2016 Jan 15;27(2):349-59
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X
Nature medicine 2016 Aug;22(8):869-78
Nature medicine 2016 Aug;22(8):869-78
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
eLife 2016 Aug 24;5
eLife 2016 Aug 24;5
Directed evolution of APEX2 for electron microscopy and proximity labeling.
Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY
Nature methods 2015 Jan;12(1):51-4
Nature methods 2015 Jan;12(1):51-4
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM
EMBO reports 2015 Aug;16(8):939-54
EMBO reports 2015 Aug;16(8):939-54
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M
Nature 2014 Jun 19;510(7505):370-5
Nature 2014 Jun 19;510(7505):370-5
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Fiesel FC, Moussaud-Lamodière EL, Ando M, Springer W
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Xu R, Hu Q, Ma Q, Liu C, Wang G
Cell death & disease 2014 Aug 14;5(8):e1373
Cell death & disease 2014 Aug 14;5(8):e1373
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW
Nature 2013 Apr 18;496(7445):372-6
Nature 2013 Apr 18;496(7445):372-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 14528-1-AP(TOM70 antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TOMM70A antibody 14528-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TOM70 (IP:14528-1-AP, 3ug; Detection:14528-1-AP 1:500) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 14528-1-AP(TOM70 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 14528-1-AP(TOM70 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
