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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14830-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14830-1-AP, RRID:AB_2212392
- Product name
- UMPS antibody
- Antibody type
- Polyclonal
- Description
- UMPS antibody (Cat. #14830-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.
Multi-omics integration reveals that pyrimidine metabolism in lung adenocarcinoma drives an immunosuppressive microenvironment.
Spermine: A prospective treatment for high glucose-induced myocardial fibrosis in db/db mice.
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.
p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas.
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.
Immunohistochemical validation study of 15-gene biomarker panel predictive of benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of JBR.10.
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study.
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients.
Tang N, Gong Y, Zhao C, Niu Y, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Lin S, Sun Y
Tumour virus research 2026 Apr 9;21:200342
Tumour virus research 2026 Apr 9;21:200342
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.
Savani MR, Li B, Smith BC, Gu W, Xiao Y, Baquer G, Shipman T, Oken SS, Manoj N, Zacharias LG, Puliyappadamba VT, Stopka SA, Regan MS, Levitt MM, Edgar CK, Hicks WH, Anand S, Martin-Sandoval MS, Winston R, S Patrício J, Johnson X, Tippetts TS, Shi DD, Lemoff A, Richardson TE, Zinn PO, Solmonson A, Mathews TP, Agar NYR, DeBerardinis RJ, Abdullah KG, McBrayer SK
Nature metabolism 2026 Apr 29;
Nature metabolism 2026 Apr 29;
Multi-omics integration reveals that pyrimidine metabolism in lung adenocarcinoma drives an immunosuppressive microenvironment.
Liu M, Li H, Xu S, Zhou Y, Yao M, Shi J, Zhong L
iScience 2026 Apr 17;29(4):115326
iScience 2026 Apr 17;29(4):115326
Spermine: A prospective treatment for high glucose-induced myocardial fibrosis in db/db mice.
Liu Y, Liu X, Li S, Xu T, Lu Y, Wang T, Yuan H
Iranian journal of basic medical sciences 2025;28(7):907-915
Iranian journal of basic medical sciences 2025;28(7):907-915
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Xu Y, Zhou W, Fan Z, Cheng Y, Xiao Y, Liu Y, Li X, Ji Z, Fan Y, Ma G
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.
Savani MR, Smith BC, Gu W, Xiao Y, Baquer G, Li B, Oken SS, Manoj N, Zacharias LG, Puliyappadamba VT, Stopka SA, Regan MS, Levitt MM, Edgar CK, Hicks WH, Anand S, Shipman T, Martin-Sandoval MS, Winston R, Patrício JS, Johnson X, Tippetts TS, Shi DD, Lemoff A, Richardson TE, Zinn PO, Solmonson A, Mathews TP, Agar NYR, DeBerardinis RJ, Abdullah KG, McBrayer SK
bioRxiv : the preprint server for biology 2025 Jul 24;
bioRxiv : the preprint server for biology 2025 Jul 24;
p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.
Choi YJ, Lee K, Lee SY, Kwon Y, Woo J, Jeon CY, Ko SG
Cancer cell international 2024 May 4;24(1):156
Cancer cell international 2024 May 4;24(1):156
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas.
Yin J, Wang X, Ge X, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, Agnihotri S, Cao Y, Ji J, Lin F, Wang Q, Zhou Q, Wang X, You Y, Lu Z, Qian X
Nature communications 2023 Sep 22;14(1):5913
Nature communications 2023 Sep 22;14(1):5913
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847
Nature cell biology 2023 Jun;25(6):836-847
Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.
Jiang X, Peng J, Xie Y, Xu Y, Liu Q, Cheng C, Yan P, Xu S, Wang Y, Zhang L, Li H, Li Y, Li B, Han J, Yu D
Cell death and differentiation 2023 Aug;30(8):1931-1942
Cell death and differentiation 2023 Aug;30(8):1931-1942
Immunohistochemical validation study of 15-gene biomarker panel predictive of benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of JBR.10.
Grieve S, Ding K, Moore J, Finniss M, Ray A, Lees M, Hossain F, Murugesan A, Agar J, Acar C, Taylor J, Shepherd FA, Reiman T
ESMO open 2020 Mar;5(2)
ESMO open 2020 Mar;5(2)
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA
Cell metabolism 2019 Jun 4;29(6):1390-1399.e6
Cell metabolism 2019 Jun 4;29(6):1390-1399.e6
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Wang Y, Bai C, Ruan Y, Liu M, Chu Q, Qiu L, Yang C, Li B
Nature communications 2019 Jan 14;10(1):201
Nature communications 2019 Jan 14;10(1):201
Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study.
Zhao HY, Chen GY, Huang Y, Li XL, Feng JF, Shi MQ, Cheng Y, Ma LX, Zhang YP, Gu CP, Song XQ, Zhou D, Zhang L
Medicine 2015 Jan;94(2):e249
Medicine 2015 Jan;94(2):e249
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients.
Zhao HY, Ma GW, Zou BY, Li M, Lin SX, Zhao LP, Guo Y, Huang Y, Tian Y, Xie D, Zhang L
OncoTargets and therapy 2014;7:1301-10
OncoTargets and therapy 2014;7:1301-10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14830-1-AP(UMPS antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-UMPS (IP:14830-1-AP, 3ug; Detection:14830-1-AP 1:500) with HEK-293 cells lysate 1700ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14830-1-AP(UMPS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UMPS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UMPS. This antibody recognizes human,mouse,rat antigen. The UMPS antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
