15264-1-AP

antibody from Proteintech Group

Targeting: ADSL

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

15264-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#15264-1-AP, RRID:AB_2225668

Product name

Adenylosuccinate lyase antibody

Antibody type

Polyclonal

Description

Adenylosuccinate lyase antibody (Cat. #15264-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Inflammaging-induced TRAF3 degradation impairs AMP biosynthesis to drive sarcopenia.

Xing Y, Fan J, Li X, Jin T, Zhang C, Dong L, Zhang X, Liu Z, Li P, Yang Q, Wu T, Boyce B, Li J
Research square 2026 Mar 20;

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Notch2 Signaling Drives Cardiac Hypertrophy by Suppressing Purine Nucleotide Metabolism.

Wang Y, Li Y, Chen S, Yu T, Sun W, Liu J, Ren H, Zhou Y, Wang L, Tao X, Du R, Shang W, Li Y, Tian D, Wang B, Shen Y, Liu Q, Yu Y
Research (Washington, D.C.) 2025;8:0635

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LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.

Zhang Y, Zhou Y, Zhang Y, Lv J, Shen Y, Zhang D, Liu B, Zhao W, Ju J, Zhu Q, Wang K, Feng N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e16809

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Mitochondrial fumarate inhibits Parkin-mediated mitophagy.

Ham SJ, Bang S, Woo D, Jo JY, Yoo T, Yoon E, Kyoung Y, Baek D, Kim JS, Chung J
Molecular cell 2025 Jun 19;85(12):2287-2302.e9

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De novo and salvage purine synthesis pathways across tissues and tumors.

Tran DH, Kim D, Kesavan R, Brown H, Dey T, Soflaee MH, Vu HS, Tasdogan A, Guo J, Bezwada D, Al Saad H, Cai F, Solmonson A, Rion H, Chabatya R, Merchant S, Manales NJ, Tcheuyap VT, Mulkey M, Mathews TP, Brugarolas J, Morrison SJ, Zhu H, DeBerardinis RJ, Hoxhaj G
Cell 2024 Jul 11;187(14):3602-3618.e20

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Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.

Jiang X, Peng J, Xie Y, Xu Y, Liu Q, Cheng C, Yan P, Xu S, Wang Y, Zhang L, Li H, Li Y, Li B, Han J, Yu D
Cell death and differentiation 2023 Aug;30(8):1931-1942

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Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Chen X, Wu M, Liang N, Lu J, Qu S, Chen H
Frontiers in cell and developmental biology 2021;9:636802

---

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I
Molecular cell 2020 Jun 18;78(6):1178-1191.e6

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 15264-1-AP(ADSL antibody) at dilution of 1:400

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using ADSL antibody 15264-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver cancer using 15264-1-AP(ADSL antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver cancer using 15264-1-AP(ADSL antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue